Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma.

Author: FarrellMariah L, ReaganMichaela R

Paper Details 
Original Abstract of the Article :
It is becoming clear that myeloma cell-induced disruption of the highly organized bone marrow components (both cellular and extracellular) results in destruction of the marrow and support for multiple myeloma (MM) cell proliferation, survival, migration, and drug resistance. Since the first phase I ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938346/

データ提供:米国国立医学図書館(NLM)

Overcoming Resistance: A Battle Against Proteasome Inhibitor Resistance in Multiple Myeloma

The battle against multiple myeloma, a type of blood cancer, continues to evolve, with new strategies constantly emerging. This research delves into the complexities of proteasome inhibitor resistance in multiple myeloma, a challenge that requires a deep understanding of the disease's intricate mechanisms. It's like navigating a shifting desert landscape, where the terrain constantly changes, demanding adaptability and innovative approaches.

Understanding Resistance: A Critical Step towards Effective Treatment

The research sheds light on both soluble and insoluble signals that contribute to proteasome inhibitor resistance in multiple myeloma cells. This knowledge is essential for developing more effective therapies and overcoming this significant obstacle in cancer treatment. It's like deciphering the secrets of a hidden oasis in the desert, a quest for knowledge that unlocks the potential for better treatment strategies.

Combating Resistance: A Collaborative Effort

This research emphasizes the need for collaborative efforts to understand and overcome proteasome inhibitor resistance. It calls for further investigation into cell-autonomous and stress-mediated mechanisms to develop more effective and targeted treatments for multiple myeloma. It's like forging a caravan of researchers, each contributing their expertise to navigate the challenging terrain of cancer research.

Dr.Camel's Conclusion

This research is a testament to the ongoing battle against multiple myeloma. The study provides valuable insights into the complexities of proteasome inhibitor resistance, highlighting the need for a multi-pronged approach to overcome this obstacle. It's a reminder that even in the face of seemingly insurmountable challenges, perseverance, collaboration, and a thirst for knowledge can lead us closer to a cure.

Date :
  1. Date Completed n.d.
  2. Date Revised 2019-11-20
Further Info :

Pubmed ID

29765356

DOI: Digital Object Identifier

PMC5938346

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.