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Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma.

Author: ChenChang-Han, HsuMei-Ling, KuoShyh-Ming, LaiJui-Chi, LinChih-Chien, LinKun-I, ShiuLi-Yen, WangYou-Qi, YouHuey-Ling

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Carnosic acid (CA) significantly inhibited the growth and proliferation of melanoma B16F10 cells by inducing cell cycle arrest at the G0/G1 phase and enhancing p21 expression. CA also enhanced the cytotoxicity and cell cycle arrest of B16F10 cells when combined with carmustine (BCNU) or lomustine (CCNU). In vivo studies showed that CA inhibits tumor growth and reduces the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). These findings suggest that CA may be a safe and effective novel chemotherapeutic agent.
Paper Details　
Original Abstract of the Article :
Carnosic acid (CA), a major polyphenolic diterpene present in <i>Rosmarinus officinalis</i>, has been reported to have multiple functions, including antitumor activity. The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and prolifer...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028752/

データ提供：米国国立医学図書館（NLM）

Carnosic Acid Enhances Anticancer Effects in Melanoma

Melanoma, a type of skin cancer, is like a desert plant that's been exposed to too much harsh sunlight, leading to uncontrolled growth. This study investigates the potential of carnosic acid (CA), a compound found in rosemary, to combat melanoma. The researchers found that CA significantly inhibits the growth of melanoma cells, arresting their cell cycle and enhancing the effectiveness of existing anticancer drugs.

Carnosic Acid's Anti-Cancer Potential

CA appears to have a promising role in fighting melanoma. It's like a resourceful desert creature using its environment to its advantage, inhibiting the harmful growth of an invasive plant. The researchers also found that CA enhances the effectiveness of existing drugs, like a desert tribe working together to overcome a challenging obstacle.

Natural Compounds in Cancer Treatment

This study highlights the potential of natural compounds like CA in fighting cancer. It's like discovering a new oasis in the desert of cancer research, offering a promising avenue for developing safer and more effective treatments. Further research is needed to fully understand the mechanisms of CA's action and its potential clinical application.

Dr. Camel's Conclusion

This research suggests that carnosic acid (CA) holds promise as a novel chemotherapeutic agent for melanoma. It's like uncovering a hidden gem in the vast desert of cancer research, offering a potential path to better treatment options. Further research is crucial to unlock the full potential of CA and its applications in fighting this challenging disease.
Date :
  1. Date Completed 2019-04-15
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29789400

DOI: Digital Object Identifier

PMC6028752

Related Literature

Article Analysis
・Effects of lomustine・Effects of carmustine
SNS
PICO Info
in preparation
Languages

English

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