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Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial.

Author: BrownCourtney V, DominelliGiulio S, DominelliPaolo B, FosterGlen E, McNeilChris J, StucklessTroy J R, SwensonErik R, TeppemaLucas J, VermeulenTyler D

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the effects of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue in healthy men. Methazolamide led to less neuromuscular fatigue than acetazolamide, suggesting a potential benefit for clinical use or in the prophylaxis of acute mountain sickness.
Paper Details　
Original Abstract of the Article :
Acetazolamide, a carbonic anhydrase (CA) inhibitor used clinically and to prevent acute mountain sickness, worsens skeletal muscle fatigue in animals and humans. In animals, methazolamide, a methylated analog of acetazolamide and an equally potent CA inhibitor, reportedly exacerbates fatigue less th...See full text at original site
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引用元：
https://doi.org/10.1152/japplphysiol.00256.2018

データ提供：米国国立医学図書館（NLM）

Acetazolamide and Methazolamide: A Desert Oasis of Muscle Strength

The world of exercise physiology is a vast and fascinating desert, where the body's response to physical exertion is a constant source of intrigue and exploration. This study investigates the impact of acetazolamide and methazolamide, carbonic anhydrase inhibitors often used clinically and to prevent acute mountain sickness, on diaphragm and dorsiflexor fatigue.

Acetazolamide and Methazolamide: A Tale of Two Carbonic Anhydrase Inhibitors

The study reveals that acetazolamide significantly worsens diaphragm and dorsiflexor fatigue, while methazolamide appears to attenuate fatigue compared to acetazolamide. These findings have implications for clinical use, suggesting that methazolamide may be a preferable option for preventing acute mountain sickness. The study also highlights the potential benefits of exploring alternative strategies to minimize muscle fatigue in individuals using carbonic anhydrase inhibitors.

Navigating the Desert of Exercise: Maintaining Muscle Strength

This study underscores the importance of understanding the potential impact of medications on muscle function, particularly in individuals engaging in physical activity. By being aware of the potential side effects of acetazolamide and considering alternative options like methazolamide, healthcare providers can ensure optimal health outcomes for patients.

Dr.Camel's Conclusion

This study investigates the impact of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue. The findings suggest that methazolamide may be a preferable option to acetazolamide in clinical settings, particularly for preventing acute mountain sickness. This research highlights the importance of understanding the potential impact of medications on muscle function and considering alternative strategies to minimize fatigue.

Date :
  1. Date Completed 2019-11-14
  2. Date Revised 2019-11-14
Further Info :

Pubmed ID

29792554

DOI: Digital Object Identifier

10.1152/japplphysiol.00256.2018

Related Literature

Article Analysis
・Effects of methazolamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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