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Fesoterodine: Pharmacological properties and clinical implications.

Author: CornuJean-Nicolas, GaméXavier, PeyronnetBenoit

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review examined fesoterodine's pharmacological properties to explain its clinical benefits for overactive bladder (OAB) in general and elderly populations. The review found that fesoterodine's high affinity for both M2 and M3 muscarinic receptors, poor blood-brain barrier penetration, lack of hepatic first-pass activation, and extended-release formulation contribute to its good balance between efficacy and tolerability.
Paper Details　
Original Abstract of the Article :
Fesoterodine (as one of three drugs: dutasteride, finasteride and fesoterodine) was classified B (beneficial) by LUTS-FORTA 2014, indicating that it is a medicinal product with proven or obvious efficacy in the elderly, with limited side effects and/or safety concerns. A systematic literature review...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2018.05.036

データ提供：米国国立医学図書館（NLM）

Fesoterodine: A Promising Solution for Overactive Bladder

Overactive bladder (OAB) is a common condition that can significantly impact quality of life. This review explores the pharmacological properties and clinical implications of fesoterodine, a medication used to treat OAB. The study delves into the specific properties of fesoterodine that contribute to its effectiveness and tolerability.

Fesoterodine's Unique Properties: Balancing Efficacy and Tolerability

The study highlights four key properties of fesoterodine that explain its clinical benefits: its high affinity for both M2 and M3 muscarinic receptors, its poor penetration of the blood-brain barrier, its lack of hepatic first-pass activation, and its extended-release formulation. These properties contribute to fesoterodine's good balance between efficacy and tolerability, making it a valuable option for treating OAB.

Fesoterodine: A Leading First-Line Treatment for Overactive Bladder

This review underscores the significant role of fesoterodine in managing OAB. Its unique pharmacological profile, combined with its proven efficacy and tolerability, has established it as one of the leading first-line treatments for this condition.

Dr. Camel's Conclusion

Fesoterodine seems like a refreshing oasis in the desert of OAB! Its unique combination of properties makes it a compelling option for managing this condition. This review reminds us that the quest for better treatments is an ongoing journey, and we're lucky to have new tools like fesoterodine to help us navigate the challenges of OAB.

Date :
  1. Date Completed 2018-10-29
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29803689

DOI: Digital Object Identifier

10.1016/j.ejphar.2018.05.036

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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