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Therapeutic Drug Monitoring of Oral Anti-Hormonal Drugs in Oncology.

Author: BeijnenJos H, GroenlandStefanie L, HuitemaAlwin D R, SchellensJan H M, SteeghsNeeltje, VerheijenRemy B, van NulandMerel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Therapeutic drug monitoring (TDM) is a valid option to further optimize treatment with oral anti-hormonal drugs used in oncology. A review of the pharmacokinetic and pharmacodynamic characteristics of these drugs suggests that individualized dosing based on measured blood concentrations is feasible and promising.
Paper Details　
Original Abstract of the Article :
Oral anti-hormonal drugs are essential in the treatment of breast and prostate cancer. It is well known that the interpatient variability in pharmacokinetic exposure is high for these agents and exposure-response relationships exist for many oral anti-hormonal drugs. Yet, they are still administered...See full text at original site
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引用元：
https://doi.org/10.1007/s40262-018-0683-0

データ提供：米国国立医学図書館（NLM）

Personalized Therapy in Oncology: The Role of Therapeutic Drug Monitoring

Imagine a vast desert landscape, where each plant represents a unique patient, with different needs for water and sunlight. This research explores the potential of personalized therapy in oncology, using therapeutic drug monitoring (TDM) to optimize treatment for patients with breast and prostate cancer.

The Challenges of Fixed Dosing

Oral anti-hormonal drugs play a crucial role in treating these cancers, but they are typically administered at fixed doses. This can lead to underdosing and suboptimal efficacy in some patients, while others may experience unnecessary side effects from overdosing.

TDM: Tailoring Treatment to the Individual

This study proposes TDM as a solution to this problem. TDM involves measuring blood concentrations of the drug and adjusting doses based on individual patient responses. This approach could lead to more effective and safer treatment, ensuring each patient receives the optimal amount of medication.

Dr. Camel's Conclusion

This research emphasizes the importance of personalized medicine, allowing us to tailor treatment to each patient's unique needs. Just as a desert plant thrives when its water needs are met, cancer patients can benefit from receiving the right dose of medication, ensuring optimal outcomes and minimizing side effects.

Date :
  1. Date Completed 2020-05-22
  2. Date Revised 2021-01-09
Further Info :

Pubmed ID

29862467

DOI: Digital Object Identifier

10.1007/s40262-018-0683-0

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English

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