Paper Details

  1. Home
  2. Paper Details

<i>In Vivo</i> Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency.

Author: BloomDavid C, LewinAlfred S, NeumannDonna M, PhelanDane M, SchultzGregory S, TuliSonal S, WashingtonShannan D, WatsonZachary L

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Herpes simplex virus (HSV) can remain dormant in nerve cells. The latency-associated transcript (LAT) region of the HSV genome plays a role in both latency establishment and reactivation. This study investigated the impact of reducing LAT levels on HSV reactivation. AAV vectors were used to deliver a LAT-targeting ribozyme to HSV-1-infected neurons of rabbits after latency establishment. Decreasing LAT levels significantly reduced the ability of the virus to reactivate. These findings suggest that LAT plays a role in reactivation independent of its function in latency establishment. This study also highlights the potential of AAV vectors expressing LAT-targeting ribozymes as a therapy for recurrent HSV disease.
Paper Details　
Original Abstract of the Article :
During herpes simplex virus (HSV) latency, most viral genes are silenced, with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long noncoding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence s...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069208/

データ提供：米国国立医学図書館（NLM）

Targeting the Herpes Simplex Virus Latency-Associated Transcript

In the ongoing battle against [herpes simplex virus (HSV)], researchers are continually searching for effective strategies to prevent and treat [reactivation from latency], a key challenge in managing this persistent infection. This study investigates the role of [the latency-associated transcript (LAT)] in HSV-1 reactivation, using [an adeno-associated virus (AAV) vector to deliver a LAT-targeting hammerhead ribozyme] to latently infected neurons.

LAT Knockdown Reduces HSV-1 Reactivation

The results of this study demonstrate that [reducing LAT levels in neurons following the establishment of latency reduces the ability of the virus to reactivate]. This finding underscores the importance of LAT in regulating HSV-1 reactivation, providing a potential target for antiviral therapies. This research opens the door for the development of novel therapeutic strategies that specifically target LAT to prevent HSV-1 reactivation.

New Strategies for HSV-1 Management

This study holds promise for the development of new therapeutic approaches for [recurrent HSV disease], such as [herpes stromal keratitis], a leading cause of infectious blindness. The researchers' findings suggest that [AAV vectors expressing LAT-targeting ribozymes could potentially serve as a therapy for recurrent HSV disease]. This research serves as a reminder that the quest for better HSV treatments is ongoing, and each new discovery brings us closer to a future where we can effectively manage this pervasive infection.

Dr.Camel's Conclusion

Imagine a desert oasis, where a hidden spring of water provides a vital source of life. This research is like discovering that spring, unveiling the role of LAT in the reactivation of HSV-1. By targeting this specific region of the virus, we may be able to develop new therapies that prevent the virus from emerging from its dormant state, offering hope for a future where HSV infections can be effectively managed.

Date :
  1. Date Completed 2018-08-17
  2. Date Revised 2019-10-23
Further Info :

Pubmed ID

29875240

DOI: Digital Object Identifier

PMC6069208

Related Literature

Article Analysis
・Effective treatment of cold sores
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.