Haemodynamic and pharmacological effects of the converting enzyme inhibitor CGS 14824A in normal volunteers.

Author: BrunnerH, BrunnerH R, BussienJ P, NussbergerJ, SchallerM D, TuriniG A, WaeberB

Paper Details 
Original Abstract of the Article :
The converting enzyme inhibitor CGS 14824A was evaluated in 15 healthy male volunteers. First, the efficacy of a single 5 or 10 mg oral dose in antagonizing the pressor response to exogenous angiotensin I was tested in 2 subjects. Blood pressure and heart rate were monitored continuously through an ...See full text at original site
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引用元:
https://doi.org/10.1007/BF00543322

データ提供:米国国立医学図書館(NLM)

The Haemodynamic and Pharmacological Effects of CGS 14824A

This research delves into the

pharmacological

world of

converting enzyme inhibitors (CEIs)

. Imagine a camel navigating a complex network of desert pathways, each turn requiring a careful adjustment. Similarly, the body's intricate systems rely on a delicate balance of hormones and enzymes, and CEIs play a crucial role in regulating these processes.

The study examines the effects of

CGS 14824A

, a CEI, on healthy volunteers. The researchers found that this drug effectively inhibited the converting enzyme, leading to a decrease in

angiotensin II

levels and a reduction in blood pressure. These findings suggest that CGS 14824A could be a promising treatment option for conditions like hypertension.

Potential for CGS 14824A in Hypertension Treatment

The results of this study suggest that CGS 14824A has the potential to be an effective treatment for hypertension. Its ability to inhibit the converting enzyme and reduce angiotensin II levels could lead to improved blood pressure control and a reduction in the risk of cardiovascular complications.

Understanding the Role of CEIs in Blood Pressure Regulation

CEIs like CGS 14824A play a critical role in regulating blood pressure. By inhibiting the converting enzyme, they effectively reduce the production of angiotensin II, a hormone that constricts blood vessels and raises blood pressure. This mechanism makes CEIs valuable tools in managing hypertension.

Dr. Camel's Conclusion

This study highlights the intricate dance between enzymes and hormones in the body. Just as a skilled navigator guides a camel through a complex desert landscape, CEIs like CGS 14824A help regulate the body's intricate systems, leading to improved health outcomes. This research offers hope for individuals facing hypertension, providing potential for a more balanced and healthier journey.

Date :
  1. Date Completed 1985-08-12
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

2988972

DOI: Digital Object Identifier

10.1007/BF00543322

Related Literature

SNS
PICO Info
in preparation
Languages

English

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