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Original Abstract of the Article :
To study the synergistic anti-tumor effects of doxorubicin and axitinib in combination, and investigate the underlying mechanism, we performed the MTT cytotoxic assay and tumor spheroids inhibition to investigate in vitro using A549 cells. The cell internalization, cell cycle distribution and DNA la...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29897727
データ提供：米国国立医学図書館（NLM）
Synergistic Anti-Tumor Effects of Axitinib and Doxorubicin: A Promising Combination
The field of [oncology] is constantly seeking innovative therapies to combat [cancer]. This study investigates the potential synergistic anti-tumor effects of combining [axitinib] and [doxorubicin], two drugs commonly used in [cancer chemotherapy].
The researchers performed in vitro experiments using [A549 cells], a lung cancer cell line. They found that the combination of axitinib and doxorubicin exerted significantly higher cytotoxicity than either drug alone, demonstrating a synergistic effect. This synergistic effect was also observed in tumor spheroid growth inhibition experiments. Furthermore, the combination achieved the highest tumor growth suppression in vivo in a [A549 xenograft] model in nude mice.
The Potential of Combining Axitinib and Doxorubicin for Cancer Treatment
This study suggests that combining axitinib and doxorubicin may offer a more effective treatment approach for certain cancers, particularly those that are resistant to single-agent therapy. The observed synergistic effects could potentially improve treatment outcomes and reduce the need for higher doses of individual drugs, potentially minimizing side effects.
The Importance of Exploring New Treatment Combinations for Cancer
This research underscores the importance of exploring new treatment combinations for cancer. By investigating the synergistic effects of different drugs, researchers can identify more effective and potentially safer therapeutic approaches for various types of cancer.
Dr.Camel's Conclusion
Just as the desert's diverse flora and fauna create a unique ecosystem, the field of oncology is exploring a myriad of therapeutic combinations to combat cancer. This study offers a promising glimpse into the potential of combining axitinib and doxorubicin, highlighting their synergistic anti-tumor effects. It's a reminder that the journey to finding effective cancer treatments often involves exploring new pathways and embracing innovative approaches.
Date :
- Date Completed 2018-08-21
- Date Revised 2018-12-02
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