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Drug resistance profiles of mutations in the RET kinase domain.

Author: HilbergFrank, LiuXuan, MooersBlaine H M, ShenTao, WuJie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Mutations in the RET kinase domain may impact the sensitivity of RET TK inhibitors used to treat thyroid and lung cancer. Further research is needed to understand the influence of these mutations on drug efficacy.
Paper Details　
Original Abstract of the Article :
Alterations in the tyrosine kinase enzyme RET are found in thyroid and lung cancer. While RET TK inhibitors (TKIs) are used to treat thyroid cancer and are in clinical trials for RET fusion-positive non-small cell lung cancer, the impact of mutations in the RET kinase domain on drug sensitivity is l...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086982/

データ提供：米国国立医学図書館（NLM）

Fighting Cancer with Precision: Understanding Drug Resistance in RET Kinase Domain Mutations

Imagine a desert where different oases have varying levels of protection. This research explores the intricate world of cancer treatment, focusing on the RET kinase domain, a key target for drugs that inhibit the growth of cancer cells.

The Importance of Understanding Drug Resistance

The study investigates how mutations in the RET kinase domain affect the sensitivity of cancer cells to RET kinase inhibitors (TKIs). Understanding these resistance mechanisms is critical for developing effective treatment strategies.

Tailoring Treatment to Overcome Resistance

This study sheds light on the diverse drug resistance profiles associated with different mutations in the RET kinase domain. This knowledge can help guide the selection of appropriate TKIs and potentially lead to the development of new strategies to overcome resistance.

Dr. Camel's Conclusion

This research highlights the importance of precision medicine in cancer treatment. Just as a desert traveler seeks out the safest oasis, we must understand the unique characteristics of each tumor to develop the most effective treatment plan.

Date :
  1. Date Completed 2019-10-02
  2. Date Revised 2022-03-24
Further Info :

Pubmed ID

29908090

DOI: Digital Object Identifier

PMC6086982

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Languages

English

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