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Micelle-Forming Dexamethasone Prodrug Attenuates Nephritis in Lupus-Prone Mice without Apparent Glucocorticoid Side Effects.

Author: BronichTatiana K, FosterKirk W, GaoYangyang, JiaZhenshan, O'DellJames R, QiuFang, ThieleGeoffrey M, WangDong, WangXiaobei, WeiXin, YuFang, YuanFang, ZhaoGang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the use of a polyethylene glycol-based macromolecular prodrug (ZSJ-0228) of dexamethasone to treat lupus nephritis (LN). ZSJ-0228 was more effective in reducing proteinuria and improving survival than daily dexamethasone, with fewer adverse effects.
Paper Details　
Original Abstract of the Article :
Nephritis is one of the major complications of systemic lupus erythematosus. While glucocorticoids (GCs) are frequently used as the first-line treatment for lupus nephritis (LN), long-term GC usage is often complicated by severe adverse effects. To address this challenge, we have developed a polyeth...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117746/

データ提供：米国国立医学図書館（NLM）

A Targeted Approach to Lupus Nephritis Treatment

Lupus nephritis, a serious complication of systemic lupus erythematosus, presents a significant challenge for physicians seeking to manage this autoimmune disease. This research explores a novel approach to treating lupus nephritis using a micelle-forming dexamethasone prodrug. The authors aim to overcome the limitations of traditional glucocorticoid therapy, which often comes with severe side effects. The study investigates the effectiveness and safety of this targeted drug delivery system in a mouse model of lupus nephritis.

ZSJ-0228: A New Hope for Lupus Nephritis

The results of this study are promising. The micelle-forming dexamethasone prodrug, ZSJ-0228, demonstrated significant effectiveness in reducing proteinuria and improving survival in lupus-prone mice. Notably, this approach appears to minimize the systemic side effects commonly associated with glucocorticoid therapy. This research suggests that ZSJ-0228 has the potential to become a safe and effective treatment option for lupus nephritis, offering a new avenue for managing this complex disease.

Lupus Nephritis: A Complex Challenge

Lupus nephritis is like a shifting sand dune, constantly evolving and requiring careful management. This research offers a glimmer of hope for individuals battling this challenging disease. The targeted delivery system of ZSJ-0228 represents a potential breakthrough, offering a safer and more effective approach to treating lupus nephritis. It highlights the importance of ongoing research and development in finding new and innovative treatments for autoimmune diseases.

Dr.Camel's Conclusion

The search for effective treatments for lupus nephritis is like a journey across a vast desert, requiring perseverance and innovative solutions. This study presents a promising new approach, utilizing a targeted delivery system to deliver dexamethasone to the inflamed kidneys. This research offers a beacon of hope for individuals with lupus nephritis, providing a glimpse of a future where this disease can be effectively managed with fewer side effects. Let’s continue to explore new horizons in the fight against autoimmune diseases.

Date :
  1. Date Completed 2019-09-30
  2. Date Revised 2019-12-28
Further Info :

Pubmed ID

29965725

DOI: Digital Object Identifier

PMC6117746

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PICO Info
in preparation
Languages

English

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