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Balancing efficacy and toxicity of targeted agents currently used for the treatment of patients with chronic lymphocytic leukemia.

Author: CaputoMaria D, De BenedittisDaniela, De LucaMaria L, FoàRobin, MauroFrancesca R, PepeSara, RosatiSerena

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the use of small molecules to treat chronic lymphocytic leukemia (CLL). While these drugs offer new chemo-free options, they can also cause unique side effects. The review highlights the importance of awareness and management of these toxicities for successful treatment.
Paper Details　
Original Abstract of the Article :
In recent years, innovative mechanism-based drugs have enriched the therapeutic armamentarium for patients with chronic lymphocytic leukemia (CLL) and are widely used in the clinical practice. These small molecules targeting the B-cell receptor signaling pathway and the BCL-2 anti-apoptotic protein ...See full text at original site
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引用元：
https://doi.org/10.1080/17474086.2018.1495557

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Chronic Lymphocytic Leukemia Treatment

[Chronic lymphocytic leukemia (CLL)] is a type of blood cancer affecting the immune system. This review examines the efficacy and toxicity of [targeted agents] currently used to treat CLL, focusing on the challenges of balancing effectiveness with potential side effects.

Balancing Efficacy and Toxicity in CLL Treatment

The review highlights the significant advancements in CLL treatment with the development of targeted agents like ibrutinib, idelalisib, and venetoclax. These agents offer new chemo-free options for patients, but they also come with unique side effects. This review emphasizes the importance of understanding and managing these toxicities for successful treatment.

Precision Medicine in CLL Treatment

This review underscores the importance of precision medicine in CLL treatment. By carefully considering the specific toxicities associated with targeted agents and individual patient factors, healthcare providers can optimize treatment plans, maximizing efficacy while minimizing adverse effects.

Dr.Camel's Conclusion

Imagine a desert filled with intricate sand formations, each with its own unique beauty and hidden dangers. Treating CLL is like navigating this complex landscape, where powerful tools exist to fight the disease, but each tool comes with its own set of challenges. This review helps us understand these challenges, guiding us towards a more nuanced and personalized approach to CLL treatment.

Date :
  1. Date Completed 2019-03-06
  2. Date Revised 2019-03-06
Further Info :

Pubmed ID

29969322

DOI: Digital Object Identifier

10.1080/17474086.2018.1495557

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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