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Some pharmacological effects of tizanidine on smooth muscle organs and alpha 2-adrenoceptor.

Author: KonnoF, KusunokiM, TakayanagiI

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Tizanidine, an alpha 2-adrenoceptor agonist, demonstrated similar potency to clonidine in inhibiting [3H]yohimbine binding. Tizanidine had no atropine-like effects, suggesting its actions are mediated through alpha 2-adrenoceptor activation. Tizanidine inhibited spontaneous movements in guinea pig ileum and rat stomach, intestinal transit in mice, and induced mydriasis in mice.
Paper Details　
Original Abstract of the Article :
Microsomal and crude synaptosomal fractions were prepared from the longitudinal muscle of guinea-pig ileum. A specific binding of [3H]yohimbine (10 nM) to alpha 2-adrenoceptor in the crude synaptosomal fraction was inhibited by tizanidine and clonidine. Tizanidine is about one-third as potent as clo...See full text at original site
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引用元：
https://doi.org/10.1016/0306-3623(85)90011-4

データ提供：米国国立医学図書館（NLM）

Tizanidine: A Smooth Muscle Regulator

This study explores the pharmacological effects of tizanidine, a medication that is commonly used to treat muscle spasms. The researchers investigated the actions of tizanidine on smooth muscle organs, specifically focusing on its interaction with alpha-2 adrenoceptors.

The Effects of Tizanidine on Smooth Muscle

The study found that tizanidine inhibits the binding of [3H]yohimbine to alpha-2 adrenoceptors in the synaptosomal fraction of guinea pig ileum. Tizanidine also inhibited spontaneous movements of guinea pig ileum and rat stomach, suggesting its ability to modulate smooth muscle activity.

Understanding the Mechanisms of Action

This study provides valuable insights into the mechanisms of action of tizanidine. The findings suggest that tizanidine exerts its effects through the activation of alpha-2 adrenoceptors, rather than through a direct action on muscarinic receptors. This knowledge is crucial for understanding the therapeutic effects of tizanidine and for developing more effective treatments for muscle spasms.

Dr.Camel's Conclusion

Just as a camel's powerful muscles allow it to navigate the harsh desert terrain, tizanidine plays a critical role in regulating smooth muscle activity. This study sheds light on the mechanisms by which tizanidine exerts its effects, providing a deeper understanding of its therapeutic potential.

Date :
  1. Date Completed 1985-12-03
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2996971

DOI: Digital Object Identifier

10.1016/0306-3623(85)90011-4

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・Effects of tizanidine
SNS
PICO Info
in preparation
Languages

English

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