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HIV anti-latency treatment mediated by macromolecular prodrugs of histone deacetylase inhibitor, panobinostat.

Author: SmithAnton A A, TolstrupMartin, ZelikinAlexander N, ZuwalaKaja

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study presents the first macromolecular prodrugs of panobinostat engineered using self-immolative linkers (SIL) and a disulfide trigger for drug release upon cell entry. These prodrugs show promising potential as latency reversing agents for HIV, offering a safer and more efficient approach to treatment.
Paper Details　
Original Abstract of the Article :
Histone deacetylase inhibitors (HDACi) and panobinostat in particular are currently in the focus of intensive investigation as latency reversing agents against the human immunodeficiency virus (HIV). Regretfully, HDACi have dose limiting side-effects making controlled, optimized methods for delivery...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003675/

データ提供：米国国立医学図書館（NLM）

HIV Anti-Latency Treatment: A New Frontier

HIV continues to be a global health challenge, and developing effective treatments remains a priority. This research explores the potential of panobinostat, a histone deacetylase inhibitor, as a latency reversing agent for HIV. The study investigates the development of macromolecular prodrugs, a novel delivery strategy for panobinostat, aimed at improving drug efficacy and reducing side effects.

Macromolecular Prodrugs: A Promising Approach for HIV Treatment

The study’s findings demonstrate the effectiveness of macromolecular prodrugs of panobinostat as latency reversing agents in cell lines harboring latent HIV. The development of these prodrugs represents a significant advancement in the fight against HIV, potentially enabling more effective and safer treatment options.

HIV: A Persistent Threat

Continued research into innovative treatment approaches for HIV is essential for improving the lives of individuals living with the virus. The development of macromolecular prodrugs holds promise for future therapies, potentially leading to more effective and tolerable treatment options.

Dr.Camel's Conclusion

Navigating the treacherous desert of HIV infection requires innovative strategies. This research offers a beacon of hope, demonstrating the potential of macromolecular prodrugs for reversing HIV latency. It highlights the importance of ongoing research and development in the quest for effective HIV treatment.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

29997778

DOI: Digital Object Identifier

PMC6003675

Related Literature

Article Analysis
・Side Effects of panobinostat
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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