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Colon cleansing efficacy and safety with 1 L NER1006 versus sodium picosulfate with magnesium citrate: a randomized phase 3 trial.

Author: , BaumgartDaniel C, ClaytonLucy B, DrenthJoost P H, FilipRafał S, HassanCesare, HylandsKerry, RepiciAlessandro, SchreiberStefan

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

The novel polyethylene glycol (PEG)-based preparation NER1006 was non-inferior to sodium picosulfate plus magnesium citrate for overall colon cleansing success and superior for high-quality cleansing of the right colon.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Polyethylene glycol (PEG) bowel preparations are widely used for precolonoscopy bowel cleansing. This phase 3 trial assessed the efficacy, safety, and tolerability of the novel 1 L PEG-based NER1006 vs. sodium picosulfate plus magnesium citrate (SP + MC) in day-before dosing. METHODS: P...See full text at original site
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引用元：
https://doi.org/10.1055/a-0639-5070

データ提供：米国国立医学図書館（NLM）

Bowel Preparation: A Comparative Study of Cleansing Solutions

Preparing for a colonoscopy can be a daunting experience, often involving unpleasant bowel cleansing procedures. This study compares the efficacy and safety of two different bowel preparation solutions, NER1006 and sodium picosulfate plus magnesium citrate (SP+MC), for pre-colonoscopy cleansing.

The researchers conducted a randomized, phase 3 trial to evaluate the cleansing effectiveness of these two solutions in patients undergoing colonoscopy. They assessed cleansing quality using the Harefield Cleansing Scale (HCS) and Boston Bowel Preparation Scale (BBPS) and compared the overall success rate and quality of right colon cleansing.

The study found that NER1006 was non-inferior to SP+MC in terms of overall cleansing success and was even superior in terms of right colon cleansing. Both solutions were well-tolerated and had acceptable safety profiles.

Navigating Bowel Preparation with Confidence

This research provides valuable information for healthcare professionals and patients undergoing colonoscopy. It offers a comparison of two common bowel preparation solutions, highlighting the effectiveness and safety of NER1006. It's like navigating a desert road – knowing which path is smoother and safer can make the journey more comfortable.

Preparing for Colonoscopy: A Guide to Choosing the Right Solution

This study provides evidence-based guidance for choosing bowel preparation solutions for pre-colonoscopy cleansing. It highlights the effectiveness of NER1006, offering a potentially more comfortable and effective option for patients.

Dr.Camel's Conclusion

This research provides valuable insights into the efficacy and safety of bowel preparation solutions for pre-colonoscopy cleansing. It offers a comparative analysis of two popular options, helping healthcare professionals and patients make informed decisions about the best approach for their individual needs.

Date :
  1. Date Completed 2019-08-29
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

30025415

DOI: Digital Object Identifier

10.1055/a-0639-5070

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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