Effect of timing of levothyroxine administration on the treatment of hypothyroidism: a three-period crossover randomized study.

Author: BakulaMiro, DumićJerka, JakupovićLejsa, KlobučarSanja Majanović, Liberati-ČizmekAna-Marija, LončarJelena Vučak, LucijanićMarko, LucijanićTomo, MarušićSrečko, MatićTomas, RahelićDario, RomićŽeljko, SkelinMarko

Paper Details 
Original Abstract of the Article :
Hypothyroidism is a common clinical problem that is successfully treated with hormone substitutes in the form of levothyroxine (LT4). LT4 is a drug with a narrow therapeutic index and is usually administered by strict rules, standardly at least half an hour before breakfast. The aim of this study wa...See full text at original site
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引用元:
https://doi.org/10.1007/s12020-018-1686-1

データ提供:米国国立医学図書館(NLM)

Timing Matters: The Impact of Levothyroxine Administration on Hypothyroidism Treatment

This [three-period crossover randomized study] investigates the [effect of timing] of [levothyroxine administration] on [thyroid function status and lipid profile] in [patients with hypothyroidism]. The authors aim to determine the [optimal time] to [administer levothyroxine] to [maximize its effectiveness]. The study found that [timing] of [levothyroxine administration] may have [a significant impact] on [thyroid function status and lipid profile]. These findings suggest that [individualizing treatment regimens] based on [the timing of levothyroxine administration] may be [beneficial] for [optimizing treatment outcomes].

Optimizing Levothyroxine Administration for Hypothyroidism

The study's findings suggest that [timing] is an important factor to consider when [treating hypothyroidism]. [Administering levothyroxine] [at least half an hour before breakfast] may be the [most effective approach] for [many patients].

Improving Hypothyroidism Management

The research highlights the [importance of individualizing treatment] for [hypothyroidism]. [Close monitoring] and [adjustments to treatment regimens] may be [necessary] to [achieve optimal thyroid function status] and [manage lipid levels].

Dr.Camel's Conclusion

Just as a camel can thrive in the desert by adapting to its environment, [hypothyroidism] management requires [a personalized approach]. This study emphasizes the [importance of timing] in [levothyroxine administration] and highlights the [need for careful monitoring] to [optimize treatment outcomes].

Date :
  1. Date Completed 2019-04-09
  2. Date Revised 2019-08-09
Further Info :

Pubmed ID

30043093

DOI: Digital Object Identifier

10.1007/s12020-018-1686-1

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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