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Mitotane in the treatment of childhood adrenocortical carcinoma: a potent endocrine disruptor.

Author: AlbertBenjamin B, CarterPhilippa J, HofmanPaul L, JefferiesCraig, LaughtonStephen, OddiePhilip D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Mitotane, a drug used for adrenocortical carcinoma (ACC), can cause various endocrine complications, including adrenal insufficiency, hypothyroidism, and, as shown in this case report, precocious puberty.
Paper Details　
Original Abstract of the Article :
Adrenocortical carcinoma (ACC) during childhood is a rare malignant tumor that frequently results in glucocorticoid and/or androgen excess. When there are signs of microscopic or macroscopic residual disease, adjuvant therapy is recommended with mitotane, an adrenolytic and cytotoxic drug. In additi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109212/

データ提供：米国国立医学図書館（NLM）

Mitotane in Childhood Adrenocortical Carcinoma: A Potent Endocrine Disruptor

This case report explores the diverse endocrine complications associated with mitotane, a medication used to treat adrenocortical carcinoma (ACC) in children. The study highlights the potential for mitotane to cause various endocrine side effects, including precocious puberty, a rare and potentially serious condition.

Understanding the Endocrine System: A Camel's Perspective

Just as a camel's hormones regulate its body temperature and water balance in the desert, the endocrine system plays a crucial role in human health. This case report highlights the importance of understanding the potential side effects of medications on the delicate balance of the endocrine system. It's like navigating a delicate ecosystem in the desert - a careful balance that can be easily disrupted.

Dr.Camel's Conclusion

This case report highlights the importance of carefully monitoring patients treated with mitotane for potential endocrine complications. It serves as a reminder that even effective treatments can have unforeseen side effects, requiring careful attention and management. It's like navigating a minefield in the desert - each step requires vigilance and careful consideration.

Date :
  1. Date Completed n.d.
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

30159150

DOI: Digital Object Identifier

PMC6109212

Related Literature

Article Analysis
・Side Effects of mitotane
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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