Paper Details

  1. Home
  2. Paper Details

Selective depletion of metastatic stem cells as therapy for human colorectal cancer.

Author: AviñóAnna, CasanovaIsolda, CéspedesMaría Virtudes, EritjaRamón, GallardoAlberto, Lopez-PousaAntonio, ManguesMaría Antònia, ManguesRamón, SalaRita, Sánchez-ChardiAlejandro, UnzuetaUgutz, VillaverdeAntonio, VázquezEsther, ÁlamoPatricia

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A nanoconjugate (T22-GFP-H6-FdU) selectively delivers Floxuridine to CXCR4+ colorectal cancer (CRC) cells, leading to their elimination and reduced metastasis. This targeted drug delivery approach effectively prevents and treats metastases, offering potential for clinical therapy.
Paper Details　
Original Abstract of the Article :
Selective elimination of metastatic stem cells (MetSCs) promises to block metastatic dissemination. Colorectal cancer (CRC) cells overexpressing CXCR4 display trafficking functions and metastasis-initiating capacity. We assessed the antimetastatic activity of a nanoconjugate (T22-GFP-H6-FdU) that se...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180303/

データ提供：米国国立医学図書館（NLM）

Metastatic Stem Cells: A Target in the Desert of Colorectal Cancer

Colorectal cancer (CRC) is a major health concern worldwide, with metastasis being a leading cause of mortality. This study investigates the potential of targeting metastatic stem cells (MetSCs), a population of cancer cells with unique properties that contribute to metastatic spread, as a novel therapeutic strategy for treating CRC.

Metastatic Stem Cells: A Potential Oasis in the Desert of Metastasis

The study demonstrates the effectiveness of a nanoconjugate that selectively delivers a chemotherapy drug, floxuridine, to CXCR4+ CRC cells, which have been identified as MetSCs. This targeted delivery approach, like a caravan carefully navigating a desert landscape, effectively eliminates MetSCs, reducing tumor re-initiation capacity and preventing the development of metastases. The findings suggest that targeting MetSCs could significantly improve the long-term outcomes of CRC treatment, offering a more effective and less invasive approach to managing this challenging disease.

Metastatic Stem Cells: A New Frontier in CRC Treatment

This study highlights the potential of nanotechnology to revolutionize cancer treatment by targeting specific subpopulations of cancer cells. The findings suggest that targeting MetSCs could significantly improve the effectiveness of CRC treatment, offering a more personalized and less toxic approach to managing this disease. It's like discovering a new oasis in the vast desert of cancer research, providing a fresh source of hope for patients and a new path towards effective treatment.

Dr. Camel's Conclusion

This study provides compelling evidence for the potential of targeting metastatic stem cells as a therapeutic strategy for colorectal cancer. The researchers' innovative approach, like a caravan navigating a complex desert landscape, offers a promising new path towards more effective and less toxic treatment options. This research, like a beacon of hope shining brightly in the desert of cancer, points towards a future where personalized therapies target specific subpopulations of cancer cells, leading to improved outcomes for patients.
Date :
  1. Date Completed 2019-05-28
  2. Date Revised 2019-05-28
Further Info :

Pubmed ID

30190334

DOI: Digital Object Identifier

PMC6180303

Related Literature

Article Analysis
・Effects of floxuridine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.