Selective serotonin reuptake inhibitors affect structure, function and metabolism of skeletal muscle: A systematic review.

Author: ChavesWenicios Ferreira, Ferraz-PereiraKelli Nogueira, LacerdaDiego Cabral, Manhães-de-CastroRaul, PereiraSabrina da Conceição, ToscanoAna Elisa, ViscoDiego Bulcão

Overview

Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat depression, but they can have negative effects on skeletal muscle. Research suggests that SSRIs may alter the electrical activity, structure, and energy metabolism of skeletal muscle in both humans and rodents. The effects varied depending on pre-existing metabolic and functional conditions.

Paper Details　

Original Abstract of the Article :

Selective Serotonin Reuptake Inhibitors (SSRIs) may have side effects, such as stiffness, tremors and altered tonic activity, as well as an increased risk of developing insulin resistance and diabetes mellitus. However, little is known about the structural, functional and metabolic changes of skelet...See full text at original site

Dr.Camel's Paper Summary Blog

Selective Serotonin Reuptake Inhibitors (SSRIs): A Journey Through the Complex Landscape of Muscle Health

This study delves into the potential effects of selective serotonin reuptake inhibitors (SSRIs), a common type of medication used to treat depression and anxiety, on skeletal muscle structure, function, and metabolism. Imagine a camel traversing a vast desert, relying on its strong muscles to navigate challenging terrain. This study explores the potential impact of SSRIs on the camel's muscular system, investigating how these medications might affect its ability to move freely and efficiently.

The researchers conducted a systematic review of studies investigating the effects of SSRIs on skeletal muscle in both humans and rodents. They analyzed data on muscle activity, structure, and metabolic processes, seeking to understand the potential implications of SSRI use for muscle health.

The review found evidence that SSRIs can alter electrical activity in skeletal muscle, potentially affecting muscle function. In addition, some studies indicated that SSRIs may influence muscle weight, the number of muscle cells, and the size of muscle fibers. The researchers also observed changes in energy metabolism, potentially affecting the way muscles use fuel.

A Shifting Landscape: Understanding the Effects of SSRIs

This review highlights the complex relationship between SSRIs and skeletal muscle. It suggests that SSRIs may have a range of effects on muscle health, potentially impacting muscle function, structure, and metabolism. Further research is needed to fully understand the implications of these findings and develop strategies to mitigate any potential negative effects.

Dr. Camel's Conclusion

Dr. Camel believes that this review provides valuable insights into the potential effects of SSRIs on skeletal muscle, reminding us that even seemingly unrelated medications can have unexpected consequences. He emphasizes the importance of consulting with a healthcare provider to discuss any potential side effects of SSRIs and explore alternative treatment options if necessary. Dr. Camel encourages patients to stay informed about the latest research and to work closely with their healthcare team to ensure they receive the best possible care, allowing them to navigate the complex landscape of their health with confidence and resilience. Remember, a healthy journey through life requires a well-maintained muscular system, allowing us to move freely and efficiently across the desert of our experiences.