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Effects of Heart Rate Reduction With Either Pyridostigmine or Ivabradine in Patients With Heart Failure: A Randomized, Double-Blind Study.

Author: CaldasJosé Antônio, KanaanSalim, MesquitaCláudio Tinoco, NevesMárcio, PortoPilar Barreto, PrechtBernardo Campanário, RodriguesLetícia Ubaldo, VillacortaAline Sterque, VillacortaHumberto, XavierAnalucia Rampazzo, da NóbregaAntônio Cláudio Lucas

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Both ivabradine and pyridostigmine significantly reduced heart rate in patients with chronic heart failure, with improvements in exercise capacity and neurohormonal and inflammatory profiles.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Heart rate (HR) reduction with ivabradine has been proved to reduce hospitalization and death from heart failure (HF). We sought to investigate whether pyridostigmine would effectively reduce HR in patients with chronic HF as compared with ivabradine. METHODS: Twenty-one patients with H...See full text at original site
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引用元：
https://doi.org/10.1177/1074248418799364

データ提供：米国国立医学図書館（NLM）

Heart Rate Reduction: A Tale of Two Drugs

In the world of heart failure, managing heart rate is crucial. This study explores the efficacy of two drugs – ivabradine and pyridostigmine – in reducing heart rate and improving the lives of patients with heart failure. The researchers conducted a double-blind study, comparing the effects of these drugs on heart rate, exercise capacity, and various biomarkers. They meticulously assessed their impact on neurohormonal and inflammatory processes in patients with chronic heart failure.

Two Approaches to Heart Rate Control

The study found that both ivabradine and pyridostigmine effectively lowered heart rate in patients with heart failure. Both drugs demonstrated improvements in exercise capacity and beneficial effects on neurohormonal and inflammatory markers. It's like two camels traversing the desert, each following a different path but ultimately reaching a similar destination. Both approaches hold promise for improving the management of heart failure.

Heart Rate and Overall Health

Heart rate is like a compass guiding our cardiovascular health. Maintaining a healthy heart rate is vital for overall well-being, especially for individuals with heart failure. This study provides valuable insights into the potential benefits of heart rate reduction using specific medications, paving the way for more effective and personalized treatment strategies.

Dr. Camel's Conclusion

This study suggests that both ivabradine and pyridostigmine can be valuable tools for managing heart rate in patients with heart failure. The research underscores the importance of individualizing treatment based on patient characteristics and preferences. It's a reminder that we are constantly learning new things about the complexity of the human heart and the many ways we can support its health.
Date :
  1. Date Completed 2020-09-10
  2. Date Revised 2020-09-10
Further Info :

Pubmed ID

30198318

DOI: Digital Object Identifier

10.1177/1074248418799364

Related Literature

Article Analysis
・Effects of pyridostigmine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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