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Acute metabolic and cardiovascular effects of mirabegron in healthy individuals.

Author: CareyAndrew L, FormosaMelissa F, KingwellBronwyn A, La GercheAndre, LohRebecca K C, ReutensAnne T

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A 100-mg dose of mirabegron increases energy expenditure and supraclavicular skin temperature in a β3-adrenoceptor-specific manner without increasing blood pressure or heart rate.
Paper Details　
Original Abstract of the Article :
AIMS: To quantify acute energy expenditure, supraclavicular skin temperature and cardiovascular responses to four doses of the β3-adrenoceptor agonist, mirabegron. MATERIALS AND METHODS: A total of 17 individuals (11 men, six women) participated in this ascending-dose study, receiving single 50-, 1...See full text at original site
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引用元：
https://doi.org/10.1111/dom.13516

データ提供：米国国立医学図書館（NLM）

Mirabegron: A Promising Drug for Bladder Control, But With Some Unexpected Side Effects

The quest for effective treatments for [bladder control] is a constant one. This study explores the impact of [mirabegron], a [β3-adrenoceptor agonist], on [energy expenditure], [skin temperature], and [cardiovascular function]. Researchers conducted a [dose-escalation study] in healthy individuals, carefully monitoring the effects of different doses of [mirabegron]. Their findings offer valuable insights into the drug's [pharmacokinetics] and potential side effects.

Mirabegron: A Balancing Act Between Benefit and Risk

The study reveals that while [mirabegron] can improve [bladder control], it may also have unintended consequences on [energy expenditure] and [cardiovascular function]. Researchers found that higher doses of [mirabegron] led to significant increases in [systolic blood pressure] and [heart rate], suggesting a need for caution. The study also highlights the potential for [mirabegron] to activate [brown adipose tissue] thermogenesis, which could have implications for [weight management].

Taking Charge of Our Health: Mirabegron's Impact On Our Daily Lives

This study emphasizes the importance of considering the potential side effects of medications, even those intended to improve [bladder control]. It highlights the need for careful monitoring and personalized treatment plans. Just as a camel carefully navigates the desert, we must carefully navigate the landscape of medication use, being aware of potential risks and seeking the guidance of healthcare professionals.

Dr.Camel's Conclusion

This research provides valuable insights into the complex effects of [mirabegron]. While offering a potential solution for [bladder control], it also reveals important considerations regarding potential side effects and the need for careful monitoring. Like a camel crossing the desert, we must approach medication use with vigilance and awareness to ensure our well-being.

Date :
  1. Date Completed 2019-09-09
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

30203462

DOI: Digital Object Identifier

10.1111/dom.13516

Related Literature

Article Analysis
・Effects of mirabegron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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