Paper Details

  1. Home
  2. Paper Details

Profile of pitolisant in the management of narcolepsy: design, development, and place in therapy.

Author: CentonzeDiego, FrancoValentina, Lo GiudiceTemistocle, RomigiAndrea, VitraniGiuseppe

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the efficacy and safety of pitolisant, a first-in-class drug for the treatment of narcolepsy. Pitolisant has been shown to be effective in treating cataplexy, daytime sleepiness, and other narcolepsy symptoms compared to placebo. It has a safe profile with headache, insomnia, and nausea being the most common side effects. Further long-term studies are needed to clarify its role in therapy and its potential as a first-line treatment option.
Paper Details　
Original Abstract of the Article :
Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness and rapid eye movement sleep dysregulation, manifesting as cataplexy and sleep paralysis, as well as hypnagogic and hypnopompic hallucinations. Disease onset may occur at any age, although adolescents and young adults ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124464/

データ提供：米国国立医学図書館（NLM）

Pitolisant: A New Hope for Narcolepsy Management

Narcolepsy, a sleep disorder that can feel like a relentless sandstorm in your mind, disrupts normal sleep patterns and can lead to excessive daytime sleepiness. This study examines pitolisant, a novel drug currently authorized by the European Medicines Agency, for the treatment of narcolepsy with or without cataplexy. The researchers reviewed the pharmacokinetic and pharmacodynamic profile of pitolisant, highlighting its effectiveness and safety in patients with narcolepsy. They analyzed the results of eight Phase II/III studies to understand the drug's impact on cataplexy episodes and subjective and objective daytime sleepiness.

Pitolisant: A Promising Treatment for Narcolepsy Symptoms

The review confirmed that pitolisant is effective in treating major narcolepsy symptoms, including cataplexy, compared to placebo. This finding provides hope for individuals struggling with the debilitating effects of narcolepsy. The study also revealed that pitolisant has a safe profile when compared to placebo and other treatments. While headache, insomnia, and nausea were the most common side effects, they were generally mild.

Living with Narcolepsy: Exploring Treatment Options

This research is a beacon of hope for individuals with narcolepsy, offering a potentially effective and safe treatment option. However, it is crucial to remember that narcolepsy is a complex condition, and the best course of treatment will vary from person to person. It is essential to consult with a qualified healthcare professional to discuss the potential benefits and risks of pitolisant and to determine the most appropriate treatment plan for your specific needs.

Dr. Camel's Conclusion

Pitolisant emerges as a new oasis in the desert of narcolepsy treatment. This research offers a promising alternative for individuals seeking to manage their symptoms and improve their quality of life. While more research is needed to fully understand its long-term effects, pitolisant represents a significant step forward in the battle against this challenging sleep disorder. Always consult with your healthcare professional to ensure you are receiving the most appropriate care.

Date :
  1. Date Completed 2018-12-17
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

30214155

DOI: Digital Object Identifier

PMC6124464

Related Literature

Article Analysis
・Side Effects of pitolisant
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.