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ADT with antiandrogens in prostate cancer induces adverse effect of increasing resistance, neuroendocrine differentiation and tumor metastasis.

Author: ChangChawnshang, GuoChangcheng, LuoJie, NiuYuanjie, TianHao, TianJing, WangKeliang, WenSimeng, YehShuyuan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Prostate cancer (PCa) is treated with androgen deprivation therapy (ADT), but many patients develop resistance. Research is exploring ways to overcome these resistances, including targeting different mechanisms involved in the development of resistance.
Paper Details　
Original Abstract of the Article :
Prostate cancer (PCa) is the most common cancer and the 2nd leading cause of cancer-related deaths among men in the United States. Androgen-deprivation-therapy (ADT) with antiandrogens to target the androgens/androgen receptor (AR) signals remains the standard therapy for advanced PCa. However, most...See full text at original site
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引用元：
https://doi.org/10.1016/j.canlet.2018.09.020

データ提供：米国国立医学図書館（NLM）

Prostate Cancer: Navigating the Shifting Sands of Treatment

Prostate cancer, a challenging journey through the desert of disease, often requires a multifaceted approach to treatment. This study delved into the complexities of androgen deprivation therapy (ADT) with antiandrogens, a common strategy for treating advanced prostate cancer. The researchers, like skilled desert guides, sought to understand the intricacies of this treatment, including its potential side effects and how to overcome them. Their findings, like a weathered map, reveal the challenges and opportunities associated with ADT and antiandrogens, guiding us toward more effective and safe treatment strategies.

The Shifting Sands: Overcoming Resistance in Prostate Cancer Treatment

The study revealed that ADT with antiandrogens can induce resistance, neuroendocrine differentiation, and tumor metastasis. This is like discovering that a seemingly safe path through the desert can lead to unexpected obstacles and detours. The findings highlight the importance of developing strategies to overcome these challenges, ensuring that treatment remains effective throughout the journey. It's a reminder that the desert of prostate cancer is dynamic and requires constant adaptation and innovation.

A More Sustainable Journey: Strategies for Effective Prostate Cancer Treatment

The study's findings prompt further research into ways to minimize the side effects of ADT and enhance its effectiveness. It's like seeking a new oasis that offers a more reliable and lasting source of water. Continued exploration of new therapies and strategies, like adjusting treatment plans and combining therapies, could lead to a more sustainable and successful journey through the desert of prostate cancer.

Dr. Camel's Conclusion

The journey through the desert of prostate cancer is often long and unpredictable. This study sheds light on the complexities of ADT and antiandrogens, emphasizing the need for ongoing research to overcome resistance and ensure a more sustainable and effective treatment journey. Like a skilled caravan leader, researchers are constantly searching for new oases of knowledge to guide us through this challenging landscape.

Date :
  1. Date Completed 2019-09-24
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

30227222

DOI: Digital Object Identifier

10.1016/j.canlet.2018.09.020

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