Effects of repurposed drug candidates nitroxoline and nelfinavir as single agents or in combination with erlotinib in pancreatic cancer cells.

Author: CamaAlessandro, De LellisLaura, De TursiMichele, FlorioRosalba, LanutiPaola, MarchisioMarco, MassucciAlberto, NatoliClara, TinariNicola, VeschiSerena, di SebastianoPierluigi

Paper Details 
Original Abstract of the Article :
Pancreatic cancer (PC) is the fourth most common cause of cancer death. Combination therapies with classical chemotherapeutic agents improved treatment of advanced PC at the cost of a relevant toxicity, but the 5-year survival rate remains below 5%. Consequently, new therapeutic options for this dis...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151049/

データ提供:米国国立医学図書館(NLM)

Effects of Repurposed Drug Candidates Nitroxoline and Nelfinavir as Single Agents or in Combination with Erlotinib in Pancreatic Cancer Cells

Pancreatic cancer, a formidable foe in the fight against cancer, can feel like a daunting desert, with limited treatment options and a low survival rate. This study, like a relentless researcher seeking a new weapon in the fight against this disease, explored the potential of repurposing existing drugs to combat pancreatic cancer. The researchers, like skilled pharmacists concocting a potent elixir, investigated the effects of nitroxoline and nelfinavir, drugs originally approved for other uses, in pancreatic cancer cells. They tested these repurposed drug candidates as single agents and in combination with erlotinib, a targeted therapy approved for pancreatic cancer treatment.

A New Path in the Desert of Pancreatic Cancer

The findings, like a well-traveled path leading through a challenging desert, revealed that nitroxoline and nelfinavir showed promising activity against pancreatic cancer cells. The study demonstrated that these repurposed drugs, when used alone or in combination with erlotinib, had a significant impact on cancer cell growth and survival. These findings suggest that repurposing existing drugs could provide new therapeutic options for pancreatic cancer patients.

Finding Hope in the Desert

Pancreatic cancer is a complex and challenging disease, but research continues to uncover new avenues of treatment. Repurposing existing drugs, like finding a hidden oasis in a vast desert, can offer hope for patients seeking effective therapies. It’s important to stay informed about the latest advancements in pancreatic cancer treatment and to consult with a healthcare professional for the most up-to-date guidance and personalized care.

Dr.Camel's Conclusion

This study, like a camel caravan venturing into a previously unexplored desert, sheds light on the potential of repurposed drugs to combat pancreatic cancer. The findings offer hope for patients seeking new treatment options and emphasize the importance of ongoing research and innovation in the field of cancer therapy.

Date :
  1. Date Completed 2018-11-09
  2. Date Revised 2018-11-14
Further Info :

Pubmed ID

30241558

DOI: Digital Object Identifier

PMC6151049

Related Literature

Article Analysis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.