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Association between HLA-B*5901 and methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis: a systematic review and meta-analysis.

Author: LohitnavyManupat, TangamornsuksanWimonchat

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Methazolamide can cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN), which are serious skin reactions. Genetic testing for HLA-B*5901 and HLA-B*5901-Cw*0102 haplotype before using methazolamide is recommended for Asian populations, as these genes are associated with an increased risk of SJS/TEN.
Paper Details　
Original Abstract of the Article :
Methazolamide-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are life-threatening adverse drug reactions. Based on previous studies, HLA genotypes may play an important role in methazolamide-induced SJS/TEN. Therefore, to identify the associations between HLA genotypes and...See full text at original site
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引用元：
https://doi.org/10.1038/s41397-018-0052-2

データ提供：米国国立医学図書館（NLM）

Methazolamide and Stevens-Johnson Syndrome: A Genetic Connection in the Sand

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), like a sudden sandstorm, can wreak havoc on the skin. This study investigates the [genetic factors] associated with [methazolamide-induced SJS/TEN], a severe adverse drug reaction. The authors conduct a [systematic review and meta-analysis] to identify potential [HLA genotypes] that may increase the risk of this condition.

The study found a statistically significant association between the [HLA-B*5901] genotype and [methazolamide-induced SJS/TEN] in [Asian populations]. This is like uncovering a hidden oasis in the desert, revealing a specific genetic vulnerability that may contribute to the development of this serious condition. The authors recommend [genetic screening] for the [HLA-B*5901] genotype before initiating [methazolamide therapy] in [Asian individuals] to minimize the risk of [SJS/TEN].

A Genetic Guide Through the Desert of Adverse Reactions

This study highlights the importance of [personalized medicine] and the potential for [genetic testing] to improve [drug safety]. It’s like using a map to navigate the desert, understanding the terrain and potential hazards to avoid dangerous routes.

Navigating the Desert of Drug Reactions

This research emphasizes the need for [awareness] of the potential [genetic factors] that can influence drug reactions. It’s a reminder that not everyone reacts to medications in the same way, and personalized approaches to treatment can improve patient outcomes. If you experience any adverse reactions to medications, it’s crucial to consult with a healthcare professional for appropriate management.

Dr.Camel's Conclusion

This study is a reminder that the desert of drug reactions can be treacherous. By understanding the genetic factors that influence our response to medications, we can navigate this terrain more safely and make informed decisions about our healthcare.

Date :
  1. Date Completed 2020-02-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

30242287

DOI: Digital Object Identifier

10.1038/s41397-018-0052-2

Related Literature

Article Analysis
・Effects of methazolamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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