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l-Serine-modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier.

Author: HayashiHidetaka, HiguchiTakahiro, HiraiNatsuko, KatsumiHidemasa, KimuraHiroyuki, KoshinoKazuhiro, MatsuuraSatoru, SakaneToshiyasu, SuzukiHiroe, YagiYusuke, YamamotoAkira

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a renal targeting drug carrier to improve drug delivery to the kidneys. Ser-PAMAM accumulated significantly in the kidneys compared to unmodified PAMAM, demonstrating its potential for treating kidney diseases. The study suggests that Ser-PAMAM is a promising renal targeting drug carrier for delivering drugs to the kidneys.
Paper Details　
Original Abstract of the Article :
Effective delivery of drug carriers selectively to the kidney is challenging because of their uptake by the reticuloendothelial system in the liver and spleen, which limits effective treatment of kidney diseases and results in side effects. To address this issue, we synthesized l-serine (Ser)-modifi...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187148/

データ提供：米国国立医学図書館（NLM）

Targeting Drug Delivery to the Kidneys: A Novel Approach

Drug delivery is a crucial aspect of medical treatment. This study focuses on developing a novel drug carrier that specifically targets the kidneys. The researchers synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a potential renal targeting drug carrier. They conducted a series of experiments in mice, evaluating the ability of Ser-PAMAM to accumulate in the kidneys and its potential as a drug delivery system for kidney diseases. The study involved injecting labeled Ser-PAMAM into mice and tracking its distribution in the body, particularly in the kidneys. The researchers also investigated the cellular mechanisms underlying Ser-PAMAM's renal accumulation.

A Targeted Delivery System

This research offers a promising approach for delivering drugs directly to the kidneys, increasing treatment efficacy and potentially reducing side effects. The study found that Ser-PAMAM effectively accumulated in the kidneys, outperforming unmodified PAMAM and other modified PAMAMs. This targeted delivery system holds significant potential for improving the treatment of kidney diseases.

A New Frontier in Drug Delivery

This research is like a hidden oasis in the desert of drug delivery, offering a novel and potentially more effective approach for targeting medications to specific organs. The development of Ser-PAMAM as a renal targeting drug carrier opens up new possibilities for treating kidney diseases, potentially leading to improved patient outcomes and a better quality of life.

Dr.Camel's Conclusion

This research exemplifies the ongoing quest for innovative drug delivery systems that target specific organs, maximizing treatment efficacy and minimizing side effects. The development of Ser-PAMAM holds significant promise for improving the treatment of kidney diseases. This study encourages continued research and development in this field, leading to more targeted and effective therapies for various medical conditions.

Date :
  1. Date Completed 2018-11-15
  2. Date Revised 2019-04-09
Further Info :

Pubmed ID

30249662

DOI: Digital Object Identifier

PMC6187148

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