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An experimental study to evaluate safety/toxicity of intravitreal natalizumab.

Author: ChawlaRohan, MokshaLaxmi, NagTapas C, NathMadhu, VelpandianThirumurthy

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Low-dose and intermediate-dose intravitreal injection of natalizumab appears safe for rabbit retina, but a high-dose injection caused functional and anatomical changes.
Paper Details　
Original Abstract of the Article :
PURPOSE: The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab). METHODS: Twelve New Zealand albino rabbits were divided into three groups (n = 4). Unilateral intravitreal injectio...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173036/

データ提供：米国国立医学図書館（NLM）

Natalizumab: Navigating the Safety Waters

Intravitreal injections, a common procedure for treating eye diseases, involve delivering medications directly into the vitreous humor, the gel-like substance filling the eye. Researchers must carefully evaluate the safety of these injections, particularly for new medications. This study investigates the safety and potential toxicity of intravitreal natalizumab, a monoclonal antibody used to treat multiple sclerosis.

A Careful Assessment

The study, a meticulous investigation into the safety of intravitreal natalizumab, revealed that low and intermediate doses of the medication appear safe for rabbit retinas. However, high-dose injections resulted in functional and anatomical changes in the retina, suggesting a potential for retinal toxicity at high concentrations.

A Dose of Caution

This research provides valuable insights into the safety of intravitreal natalizumab, highlighting the importance of careful dose selection and ongoing monitoring to minimize potential risks.

Dr.Camel's Conclusion

This study serves as a reminder that even in the seemingly calm waters of intravitreal injections, there can be hidden currents. The researchers have meticulously charted a course, providing valuable data for navigating the safety considerations of this therapeutic approach.

Date :
  1. Date Completed 2018-10-23
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

30249830

DOI: Digital Object Identifier

PMC6173036

Related Literature

Article Analysis
・Effects of natalizumab injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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