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Lorcaserin decreases the reinforcing effects of heroin, but not food, in rhesus monkeys.
Author: BergmanJack, KohutStephen J
Original Abstract of the Article :
Preclinical studies indicate that lorcaserin (Belviq®), an FDA-approved serotonin 2 C receptor agonist, may be a promising medication for the treatment of stimulant addiction. However, few studies have investigated its effects on self-administration of drugs of abuse from other pharmacological class...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/30268662
データ提供:米国国立医学図書館(NLM)
Lorcaserin: A Potential Treatment for Opioid Addiction?
The world of drug addiction research is a vast and complex desert, filled with challenges and mysteries. One particularly challenging area is the search for effective treatments for opioid addiction. This research, published in the journal Neuropsychopharmacology, delves into the potential of lorcaserin, an FDA-approved medication for weight loss, as a treatment for opioid addiction. The study used rhesus monkeys as a model for human addiction, a common practice in this field as these monkeys are highly susceptible to opioid addiction. This study investigated the effects of lorcaserin on both heroin and food self-administration in these monkeys. The researchers discovered that lorcaserin selectively decreased heroin intake without impacting food intake, suggesting a possible avenue for treating opioid addiction without causing unwanted effects on food intake. This finding is quite fascinating and promising, as it suggests a potential new treatment for opioid addiction that might not impact food intake. This research has implications for the development of new treatments for opioid addiction.
Lorcaserin: A Targeted Approach to Opioid Addiction
The research showed that lorcaserin decreased heroin intake by selectively reducing its reinforcing strength. This finding suggests that lorcaserin might help to break the cycle of addiction by reducing the pleasurable effects of opioids without impacting the desire for food. It's like trying to quench a thirst in a desert with a specific water source, rather than just any water source. This targeted approach could be key in helping individuals break free from the hold of addiction and regain control over their lives.
Lorcaserin: A New Hope for Opioid Addiction Treatment?
The findings of this study suggest that lorcaserin may be a promising new treatment option for opioid addiction. The selective nature of lorcaserin's effects on opioid self-administration is particularly encouraging. By reducing the rewarding effects of opioids without affecting food intake, lorcaserin could potentially provide a safer and more effective treatment option for individuals struggling with opioid addiction. This research is a glimmer of hope in the vast, sometimes seemingly endless desert of opioid addiction. We need to continue to investigate this promising avenue and explore its potential for treating opioid addiction in humans.
Dr. Camel's Conclusion
This study on lorcaserin is a promising development in the search for new opioid addiction treatments. Its selective impact on opioid self-administration, without affecting food intake, suggests a potentially safer and more effective approach for individuals battling addiction. While further research is needed, the findings offer a glimmer of hope in the vast, challenging desert of opioid addiction.
Date :
- Date Completed 2019-01-22
- Date Revised 2019-12-10
Further Info :
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