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Antitumor effects and mechanisms of olaparib in combination with carboplatin and BKM120 on human triple‑negative breast cancer cells.

Author: HuYunhui, YangQianxi, ZhangJin, ZhaoHui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of a combination of CBP, olaparib, and BKM120 on TNBC cells. The study found that the drug combination was cytotoxic to TNBC cells, both with regards to short-term and long-term sensitivity, and they exerted strong synergistic effects.
Paper Details　
Original Abstract of the Article :
Triple‑negative breast cancer (TNBC) refers to a heterogeneous group of tumors, for which there is currently a lack of targeted therapies. Poly(ADP‑ribose) polymerase (PARP) inhibitors, phosphatidylinositol 3‑kinase (PI3K) inhibitors and carboplatin (CBP) have demonstrated sufficient efficacy and sa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196642/

データ提供：米国国立医学図書館（NLM）

Antitumor Effects and Mechanisms of Olaparib in Combination with Carboplatin and BKM120 on Human Triple-Negative Breast Cancer Cells

This research, like a skilled chemist carefully mixing ingredients, investigates the potential of combining three drugs - olaparib, carboplatin, and BKM120 - to treat triple-negative breast cancer (TNBC). The study examines the antitumor effects of this combination, exploring its mechanisms of action and potential synergistic effects. The findings suggest that this combination could be a promising therapeutic strategy for TNBC, offering hope for a more effective treatment approach for this aggressive cancer type.

A Powerful Combination: Targeting Triple-Negative Breast Cancer

This research, like a caravan carefully navigating a treacherous desert, explores the potential of combining three drugs - olaparib, carboplatin, and BKM120 - to treat triple-negative breast cancer (TNBC). The study found that this combination exerted strong synergistic effects, demonstrating significant antitumor activity against TNBC cells. This research offers a potential new weapon in the fight against TNBC, providing hope for more effective treatment options for patients.

A Holistic Approach: Combating Triple-Negative Breast Cancer

This research, like a wise camel seeking a holistic approach to traversing the desert of cancer treatment, explores the potential of combining three drugs - olaparib, carboplatin, and BKM120 - to treat triple-negative breast cancer (TNBC). The study found that this combination significantly inhibited TNBC cell growth and proliferation, suggesting that this approach could lead to more effective and personalized treatment strategies for this aggressive cancer type.

Dr. Camel's Conclusion

This research, like a camel navigating the vast and complex desert of cancer research, explores the potential of a combination of three drugs - olaparib, carboplatin, and BKM120 - to treat triple-negative breast cancer (TNBC). The study's findings suggest that this combination could be a promising therapeutic strategy for TNBC, offering a potential new weapon in the fight against this aggressive cancer type. This research serves as a reminder that the pursuit of innovative and effective treatments for cancer is a continuous journey, and combining multiple therapeutic approaches can lead to significant breakthroughs.
Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

30272286

DOI: Digital Object Identifier

PMC6196642

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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