Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial.

Author: Al-HendyAyman, ArcherDavid F, BradleyLinda, CarrBruce R, ChwaliszKristof, DiamondMichael P, DuanW Rachel, DufekMatthew B, GaoJingjing, OwensCharlotte D, SimonJames A, SolimanAhmed M, StewartElizabeth A, WattsNelson B

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To evaluate elagolix, an oral gonadotropin-releasing hormone receptor antagonist, alone or with add-back therapy, in premenopausal women with heavy menstrual bleeding (greater than 80 mL per month) associated with uterine leiomyomas. METHODS: This double-blind, randomized, placebo-contro...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/30303923

データ提供:米国国立医学図書館(NLM)

Treating Heavy Menstrual Bleeding: Elagolix Takes the Stage

Heavy menstrual bleeding is like a desert flood, causing significant discomfort and disrupting daily life. This study explores the effectiveness of [elagolix], an oral medication that blocks the production of hormones, in treating women with [heavy menstrual bleeding] associated with [uterine leiomyomas]. The study compared the effectiveness of elagolix alone and with different doses of [add-back therapy], which helps to mitigate the potential side effects of hormone suppression.

A New Oasis for Women's Health

The study showed that elagolix, both with and without add-back therapy, significantly reduced [menstrual blood loss] in women with uterine leiomyomas. This is like finding a way to control the flow of a desert flood, providing relief and restoring a sense of balance. The study also found that add-back therapy helped to prevent [hypoestrogenic effects] on [bone mineral density], demonstrating the importance of considering the potential impact of hormonal treatments on overall health.

Managing the Effects of Hormone Suppression

The research emphasizes the importance of finding the right balance when managing hormonal conditions. Just like a desert oasis needs a delicate balance of water and shade, women with heavy menstrual bleeding may benefit from a personalized approach that considers both the benefits and potential risks of hormone suppression. Further research is needed to understand the long-term impact of elagolix and to develop strategies for minimizing side effects and ensuring optimal patient outcomes.

Dr. Camel's Conclusion

This study highlights the potential of elagolix as a promising treatment option for women with heavy menstrual bleeding associated with uterine leiomyomas. While the study demonstrates its efficacy, it also emphasizes the need for careful monitoring and personalized management to ensure optimal outcomes and address potential side effects. The research offers hope for finding new solutions to manage this challenging condition and improve the quality of life for women who experience heavy menstrual bleeding.

Date :
  1. Date Completed 2019-09-25
  2. Date Revised 2021-03-18
Further Info :

Pubmed ID

30303923

DOI: Digital Object Identifier

NIHMS1672096

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Languages

English

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