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Discovery of a Novel Inhaled PI3Kδ Inhibitor for the Treatment of Respiratory Diseases.
Author: BernalFrancisco Javier, BravoMónica, CalamaElena, CalbetMarta, CarrascalMarta, CaturlaJuan Francisco, DomínguezMaría, ErraMontse, EspinosaSònia, GràciaJordi, HernándezBegoña, LehnerMartin D, MaldonadoMónica, MirMarta, MiralpeixMontserrat, PagèsLluís, ParisStéphane, SabatéMar, TaltavullJoan
Original Abstract of the Article :
Oral PI3Kδ inhibitors such as Idelalisib and Duvelisib have shown efficacy as anticancer agents and Idelalisib has been approved for the treatment of three B-cell cancers. However, Idelalisib has a black box warning on its product label regarding the risks of fatal and serious toxicities including h...See full text at original site
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引用元:
https://doi.org/10.1021/acs.jmedchem.8b00873
データ提供:米国国立医学図書館(NLM)
Inhaled PI3Kδ Inhibitors: A Promising Approach for Respiratory Diseases
The pursuit of effective treatments for respiratory diseases is a continuous journey, akin to a camel caravan traversing a vast desert. This article explores the development of inhaled PI3Kδ inhibitors, a novel approach for treating severe asthma and COPD. Researchers sought to optimize the therapeutic index of PI3Kδ inhibitors by delivering them directly to the lungs, minimizing undesired side effects associated with oral administration.Inhaled PI3Kδ Inhibitors: A Potential Breakthrough for Respiratory Diseases
The discovery of LAS195319, a promising inhaled PI3Kδ inhibitor, represents a potential breakthrough in the treatment of severe asthma and COPD. This targeted approach offers the potential to deliver effective therapy directly to the site of action while minimizing systemic side effects. Imagine the desert as a vast and challenging landscape, and the inhaled PI3Kδ inhibitor as a precise and efficient guide, navigating the terrain directly to the intended destination.Navigating the Complexities of Respiratory Disease Treatment
This article highlights the ongoing efforts to develop innovative and targeted therapies for respiratory diseases. Like exploring the diverse and ever-changing desert landscape, researchers are constantly seeking new approaches to improve treatment outcomes and patient well-being.Dr.Camel's Conclusion
The development of inhaled PI3Kδ inhibitors offers a promising new approach for treating respiratory diseases like severe asthma and COPD. Like a skilled camel driver navigating a treacherous desert, this targeted therapy aims to deliver effective relief directly to the site of action, minimizing potential risks and improving patient outcomes.Date :
- Date Completed 2019-09-19
- Date Revised 2019-09-19
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