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Druggability of Coronary Artery Disease Risk Loci.

Author: AlshabeebMohammad, AsselbergsFolkert W, BarnesMichael R, BrænneIngrid, ErdmannJeanette, HemerichDaiane, LempiäinenHarri, MooreJason H, PatelRiyaz S, SchunkertHeribert, TraganteVinicius, den RuijterHester M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Two pipelines have been developed to identify drugs suitable for repurposing for coronary artery disease and myocardial infarction, using integrated data on genome-wide association studies loci, drug-gene interactions, side effects, and chemical interactions.
Paper Details　
Original Abstract of the Article :
Genome-wide association studies have identified multiple loci associated with coronary artery disease and myocardial infarction, but only a few of these loci are current targets for on-market medications. To identify drugs suitable for repurposing and their targets, we created 2 unique pipelines int...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30354342

データ提供：米国国立医学図書館（NLM）

Druggability of Coronary Artery Disease Risk Loci: Finding New Targets for Treatment

Coronary artery disease (CAD) is a formidable foe, a desert storm that can wreak havoc on the heart. Researchers are constantly seeking new ways to prevent and treat this condition. This study explores the potential for repurposing existing drugs for treating CAD, focusing on specific genetic regions linked to the disease. It's like searching for a hidden oasis in a vast and unforgiving desert, hoping to find a source of healing and resilience.

The study utilizes a sophisticated approach, integrating vast datasets on genetic associations, drug-gene interactions, and side effects. It's like using a combination of maps, compasses, and telescopes to navigate the vast desert of biological information. The study's findings identify potential drug targets and existing drugs that could be repurposed for treating CAD, offering a potential shortcut through the desert of complex disease pathways.

New Hope for Coronary Artery Disease: Repurposing Existing Drugs

This study offers hope for patients with CAD. The findings suggest that repurposing existing drugs could provide new treatment options, potentially improving patient outcomes. It's like discovering a new wellspring of water in a parched desert, offering a source of life and hope.

New Hope for Coronary Artery Disease: Repurposing Existing Drugs

This study offers hope for patients with CAD. The findings suggest that repurposing existing drugs could provide new treatment options, potentially improving patient outcomes. It's like discovering a new wellspring of water in a parched desert, offering a source of life and hope.

Dr.Camel's Conclusion

This study is a valuable contribution to the fight against CAD. The insights gained from analyzing genetic data and drug-gene interactions offer a promising path forward in the search for new treatments. It's like using the stars to guide your way through a dark desert, providing a roadmap to a healthier future. This study is a reminder that even in the face of daunting challenges, there is always hope for finding a path to a better outcome.

Date :
  1. Date Completed 2019-09-26
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

30354342

DOI: Digital Object Identifier

NIHMS976601

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Languages

English

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