Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the genitourinary syndrome of menopause.

Author: , ArcherDavid F, BScAdam Beauregard, BalserJohn, CôtéIsabelle, FrenetteLouise, KoltunWilliam, LabrieFernand, LavoieLyne, MartelCéline, MontesinoMarlene, MoyneurÉrick, ParentJulie, PortmanDavid, VachonAndrée, VaillancourtMario, YoungDouglas

Paper Details 
Original Abstract of the Article :
OBJECTIVE: The aim of this study is to confirm the local beneficial effects of intravaginal dehydroepiandrosterone (DHEA, Prasterone) on moderate to severe dyspareunia or pain at sexual activity, the most frequent symptom of vulvovaginal atrophy due to menopause or genitourinary syndrome of menopaus...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/30358731

データ提供:米国国立医学図書館(NLM)

Vaginal Dryness and Pain? Dehydroepiandrosterone (DHEA) Might Be the Oasis You're Looking For

This study dives deep into the desert of menopause, exploring the use of intravaginal dehydroepiandrosterone (DHEA) as a potential oasis for women experiencing the discomfort of vaginal dryness and painful intercourse. The research is akin to a treasure hunt, meticulously analyzing the effects of DHEA on key indicators of vaginal health, like the number of different types of cells in the vaginal lining, pH balance, and the severity of pain during intimacy. The researchers conducted a double-blind, placebo-controlled trial with a group of 157 women who received a placebo and 325 women who were given DHEA daily for 12 weeks. This rigorous approach ensures reliable results, akin to navigating a sandstorm with the best compass and map. The results are quite promising, showing a statistically significant improvement in all measured parameters in the DHEA group compared to the placebo group. It's like finding a hidden spring in the desert!

DHEA: A Potential Lifeline for Vaginal Atrophy

The research reveals that DHEA acts like a revitalizing spring, improving vaginal health parameters and significantly reducing pain during intimacy. This could be a game-changer for women experiencing vulvovaginal atrophy, a condition that affects many women during menopause. The results demonstrate a significant decrease in pain severity, a decrease in vaginal pH, and an increase in healthy vaginal cells. These findings are like discovering a lush garden within a barren desert landscape.

A New Path Forward: DHEA and Vaginal Health

The study offers a glimmer of hope for women struggling with the symptoms of vaginal atrophy. This research suggests that DHEA could be a valuable tool for improving quality of life for women experiencing these challenges. By understanding the mechanisms of how DHEA works, we might be able to develop even more effective treatments for vaginal atrophy in the future. Imagine a vast desert landscape where new oases are being discovered, providing relief and rejuvenation to those who need it most.

Dr.Camel's Conclusion

This groundbreaking study presents a compelling case for the potential of DHEA as a safe and effective treatment for vaginal atrophy. Its local action and minimal side effects make it a promising therapeutic option for women seeking to alleviate the discomfort associated with menopause.
Date :
  1. Date Completed 2019-11-05
  2. Date Revised 2022-07-26
Further Info :

Pubmed ID

30358731

DOI: Digital Object Identifier

00042192-201811000-00024

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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