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Pharmacotherapy of obesity: Available medications and drugs under investigation.

Author: FarrOlivia M, MantzorosChristos S, Nolen-DoerrEric, PapathanasiouAimilia-Eirini, PerakakisNikolaos, PilitsiEleni, PolyzosStergios A

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Obesity affects over 500 million people globally. While lifestyle changes are crucial, they often fail to achieve long-term weight loss. FDA-approved medications like orlistat, lorcaserin, and others can aid in weight loss (5-10%), leading to improved cardiovascular and metabolic health. This review discusses existing and future anti-obesity drugs.
Paper Details　
Original Abstract of the Article :
Obesity is a chronic disease with a continuously rising prevalence that currently affects more than half a billion people worldwide. Energy balance and appetite are highly regulated via central and peripheral mechanisms, and weight loss triggers a homeostatic response leading to weight regain. Lifes...See full text at original site
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引用元：
https://doi.org/10.1016/j.metabol.2018.10.010

データ提供：米国国立医学図書館（NLM）

Pharmacotherapy of Obesity: A Camel's Journey Through the Shifting Sands of Weight Management

Obesity is a growing global concern, like a desert that seems to expand with each passing year. This research explores the use of pharmacotherapy in managing obesity, examining the available medications and drugs under investigation. It highlights the limitations of lifestyle and behavioral modifications alone and emphasizes the role of medications in achieving and sustaining weight loss.

Pharmacotherapy: A Tool in the Obesity Management Toolkit

The study provides an overview of FDA-approved medications for obesity management, including orlistat, lorcaserin, phentermine/topiramate, liraglutide, and naltrexone/bupropion. It also discusses the potential of anti-obesity agents currently in the pipeline. The authors emphasize that pharmacotherapy should be considered in conjunction with lifestyle modifications and that even modest weight loss can offer significant health benefits.

A Camel's Perspective: The Importance of a Multi-faceted Approach

The desert of obesity is a challenging terrain to navigate, requiring a multifaceted approach. This research highlights the importance of considering pharmacotherapy as a tool alongside lifestyle modifications. By embracing a holistic perspective, we can create a more effective and sustainable strategy for weight management.

Dr. Camel's Conclusion

The fight against obesity is a journey through a vast and complex desert. This research provides valuable insights into the potential of pharmacotherapy as a tool for weight management. By understanding the latest developments in obesity treatment and adopting a holistic approach, we can work towards a healthier future for individuals struggling with this challenging condition.

Date :
  1. Date Completed 2019-11-25
  2. Date Revised 2019-11-25
Further Info :

Pubmed ID

30391259

DOI: Digital Object Identifier

10.1016/j.metabol.2018.10.010

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Languages

English

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