Safety profile of trifluridine/tipiracil monotherapy in clinical practice: results of the German compassionate-use program for patients with metastatic colorectal cancer.

Author: FuchsMartin, KarthausMeinolf, KasperStefan, KisroJens, MüllerChristian, RafiyanMohammad-Reza, Schulz-AbeliusArmin, SteinAlexander

Paper Details 
Original Abstract of the Article :
Trifluridine/tipiracil (TAS-102, Lonsurf®), a novel oral anti-tumor agent combining an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiracil hydrochloride, TPI) presents a new treatment option for metastatic colorectal cancer (mCR...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240219/

データ提供:米国国立医学図書館(NLM)

A New Hope for Metastatic Colorectal Cancer Patients

The world of oncology is constantly evolving, seeking new and innovative ways to combat cancer. This research delves into the realm of metastatic colorectal cancer (mCRC), a particularly challenging form of the disease. The study focuses on a novel oral anti-tumor agent called trifluridine/tipiracil (TAS-102, Lonsurf®), which combines an anti-neoplastic thymidine-based nucleoside analogue (trifluridine, FTD) with a thymidine phosphorylase inhibitor (tipiracil hydrochloride, TPI). The researchers aimed to evaluate the safety profile of this promising treatment option for mCRC patients who have not responded well to standard therapies or who cannot tolerate them. Their findings are based on data gathered from a German compassionate-use program.

Safety Profile of a New Treatment Option

The study highlights the safety profile of trifluridine/tipiracil, emphasizing its potential as a viable option for mCRC patients. The results indicate that this drug exhibits a favorable safety profile, making it a promising prospect for those who have exhausted other treatment possibilities.

Navigating the Desert of Cancer Treatment

Think of the mCRC patients as travelers lost in a vast desert, searching for an oasis of hope. This research presents a new water source in the form of trifluridine/tipiracil, offering a lifeline to those who have struggled to find relief. While further studies are necessary to fully understand its long-term impact, this drug holds great promise for improving the quality of life for these patients.

Dr. Camel's Conclusion

This research holds immense potential in the fight against mCRC. Trifluridine/tipiracil presents a glimmer of hope for patients who are desperately seeking effective treatments. As with any new drug, continued research and clinical trials are essential to fully understand its benefits and risks. However, the initial findings are encouraging, and this drug could become a valuable addition to the arsenal of weapons against this challenging disease.

Date :
  1. Date Completed 2019-02-28
  2. Date Revised 2019-02-28
Further Info :

Pubmed ID

30445951

DOI: Digital Object Identifier

PMC6240219

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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