Paper Details

  1. Home
  2. Paper Details

Discovery of naldemedine: A potent and orally available opioid receptor antagonist for treatment of opioid-induced adverse effects.

Author: GotoYoshihisa, HagaNobuhiro, HaraShinichiro, HasegawaTsuyoshi, InagakiMasanao, KaiHiroyuki, KanemasaToshiyuki, KoikeKatsumi, KumeMasaharu, NakamuraTakashi, OonishiShuuichi, TamuraYoshinori

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Peripherally restricted dual antagonists for μ/δ-opioid receptors were discovered that inhibit opioid-induced constipation and emesis/vomiting with limited potential to interfere with the analgesic effects of morphine. Naldemedine was selected as a potential drug candidate.
Paper Details　
Original Abstract of the Article :
Structure-activity relationship studies of several morphinan derivatives were conducted to obtain dual antagonists for μ- and δ-opioid receptors. We discovered peripherally restricted dual antagonists for μ/δ-opioid receptors as a new chemotype with a morphinan scaffold, which are orally available a...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.bmcl.2018.11.007

データ提供：米国国立医学図書館（NLM）

A New Weapon in the Fight Against Opioid-Induced Side Effects

Opioids are powerful pain relievers, but they can also cause unpleasant side effects such as constipation and vomiting. This study focuses on the discovery of naldemedine, a potent and orally available opioid receptor antagonist, for the treatment of opioid-induced adverse effects. The authors describe the development of naldemedine as a potential drug candidate, highlighting its unique properties and potential benefits for patients.

Targeting the Roots of Opioid Side Effects

The study emphasizes the importance of developing new therapies to manage the side effects of opioid medications. Naldemedine, a peripherally restricted dual antagonist for μ/δ-opioid receptors, offers a promising solution for reducing opioid-induced constipation and emesis/vomiting without interfering with the analgesic effects of morphine. This research highlights the potential of targeted therapies to improve patient outcomes and enhance the overall benefits of opioid pain management.

Improving Opioid Safety and Efficacy

This study offers a new tool in the arsenal for managing opioid-induced side effects. Naldemedine, with its unique properties and targeted action, holds the promise of improving patient outcomes and enhancing the safety and efficacy of opioid pain management. This research encourages further investigation into the potential of naldemedine as a valuable treatment option for patients experiencing opioid-induced adverse effects.

Dr.Camel's Conclusion

This study showcases the power of scientific innovation in addressing the challenges associated with opioid pain management. Naldemedine, a novel drug with a targeted mechanism of action, holds the promise of reducing opioid-induced side effects and improving patient outcomes. This research is a testament to the ongoing efforts to develop safer and more effective pain management strategies.

Date :
  1. Date Completed 2019-11-04
  2. Date Revised 2022-08-16
Further Info :

Pubmed ID

30446313

DOI: Digital Object Identifier

10.1016/j.bmcl.2018.11.007

Related Literature

Article Analysis
・Effects of naldemedine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.