Paper Details

  1. Home
  2. Paper Details

Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice.

Author: ChenYuan-Hua, FeiJun, FuLin, HuBiao, LiJia-Bin, XuDe-Xiang, ZhaoHui

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of obeticholic acid (OCA), an agonist of FXR, on Lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. OCA prevented LPS-induced ALI by enhancing pulmonary FXR activity and blocking inflammatory signaling pathways.
Paper Details　
Original Abstract of the Article :
Acute lung injury (ALI) is a common disease that may result in acute respiratory failure and death. However, there are still no effective treatments for ALI. Several studies have shown that farnesoid X receptor (FXR) has an anti-inflammatory effect. We investigated the effects of obeticholic acid (O...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.intimp.2018.11.005

データ提供：米国国立医学図書館（NLM）

Obeticholic Acid: A Potential Savior for Acute Lung Injury

Acute lung injury (ALI) is a serious condition that can lead to acute respiratory failure and death. There is currently no effective treatment for ALI, but this research explores the potential of obeticholic acid (OCA), an agonist of the farnesoid X receptor (FXR), as a therapeutic agent. The study investigates the effects of OCA on lipopolysaccharide (LPS)-induced ALI in mice.

OCA: A Multifaceted Anti-Inflammatory Agent

The results suggest that OCA has protective effects against LPS-induced ALI in mice. OCA enhanced pulmonary FXR activity and prevented LPS-induced ALI by blocking several inflammatory signaling pathways, including NF-κB. This study highlights the potential of OCA as a multifaceted anti-inflammatory agent that could be a valuable tool for treating ALI.

A New Dawn for ALI Treatment

This research offers a glimmer of hope for patients with ALI. The findings suggest that OCA, by targeting the FXR pathway and modulating inflammatory responses, could be a promising treatment for this serious condition. Just like a camel navigating treacherous sandstorms, researchers are constantly seeking new strategies to combat diseases like ALI.

Dr. Camel's Conclusion

Just as a camel traverses the vast desert, seeking out life-giving oases, researchers are on a journey to find effective treatments for acute lung injury (ALI). This study, like a refreshing oasis, highlights the potential of obeticholic acid (OCA) in combating this serious condition. The research suggests that OCA, by targeting the farnesoid X receptor (FXR) pathway and modulating inflammatory responses, could provide a new avenue for treating ALI.
Date :
  1. Date Completed 2019-05-14
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

30468885

DOI: Digital Object Identifier

10.1016/j.intimp.2018.11.005

Related Literature

Article Analysis
・Effects of obeticholic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.