Vincristine and prednisone prolong the survival of patients receiving intravenous or oral melphalan for multiple myeloma: Cancer and Leukemia Group B experience.

Author: BrunnerK, ColemanM, CooperM R, CornwellG G, GlowienkaL P, HendersonE, KochwaS, McIntyreO R, PajakT F, RaflaS

Paper Details 
Original Abstract of the Article :
A total of 589 patients with previously untreated multiple myeloma were randomized to receive daily oral melphalan, pulse-dose intravenous (IV) melphalan, carmustine (BCNU), or lomustine (CCNU). All patients received an initial tapering course of prednisone (Pred). During week 22 (day 154), patients...See full text at original site
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引用元:
https://doi.org/10.1200/JCO.1988.6.9.1481

データ提供:米国国立医学図書館(NLM)

Combating Multiple Myeloma: A Battle in the Desert of Cancer

The battle against cancer is a vast and challenging desert, where researchers tirelessly seek effective weapons against this formidable foe. This study, like a strategic military campaign, investigates the impact of vincristine and prednisone on the survival of patients with multiple myeloma, a type of blood cancer. The researchers conducted a randomized clinical trial, comparing the effects of various treatment regimens on patient outcomes.

Vincristine and Prednisone: A Powerful Alliance in the Desert

The study found that the addition of vincristine and prednisone to melphalan therapy, a standard treatment for multiple myeloma, significantly prolonged survival, like a well-equipped caravan with additional provisions. This combination therapy was more effective in converting non-responders to responders, demonstrating its ability to overcome resistance and achieve better outcomes.

Hope for Multiple Myeloma Patients: A Glimpse of a Brighter Oasis

This research, like a well-traveled path through the desert, offers a glimmer of hope for patients with multiple myeloma. The findings highlight the effectiveness of a combination therapy approach, providing a potential path towards improved survival and quality of life.

Dr. Camel's Conclusion

This study, like a beacon in the desert, illuminates a promising avenue for treating multiple myeloma. The findings offer a new strategy for battling this formidable disease, bringing hope to patients and inspiring continued research efforts.

Date :
  1. Date Completed 1988-10-25
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

3047338

DOI: Digital Object Identifier

10.1200/JCO.1988.6.9.1481

Related Literature

SNS
PICO Info
in preparation
Languages

English

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