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Effects of secondary EGFR mutations on resistance against upfront osimertinib in cells with EGFR-activating mutations in vitro.

Author: ChibaMasato, FujinoToshio, KobayashiYoshihisa, KogaTakamasa, MitsudomiTetsuya, NishinoMasaya, OharaShuta, ShimojiMasaki, SudaKenichi, TakemotoToshiki, TomizawaKenji

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated whether resistance mutations that emerged with T790 M were responsible for the osimertinib resistance in the first-line setting.
Paper Details　
Original Abstract of the Article :
Non-small cell lung cancers (NSCLCs) that harbor activating mutations for epidermal growth factor receptor (EGFR) show remarkable initial response to EGFR-tyrosine kinase inhibitors (TKIs), but inevitably acquire resistance, half of which are due to a T790 M secondary mutation when first-generation ...See full text at original site
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引用元：
https://doi.org/10.1016/j.lungcan.2018.10.026

データ提供：米国国立医学図書館（NLM）

Unraveling Resistance to Osimertinib in EGFR-Mutated Lung Cancers

This research investigates the mechanisms of resistance to osimertinib, a targeted therapy for non-small cell lung cancer (NSCLC). It's like exploring a hidden cave system in the desert, uncovering new pathways and understanding the complex interplay of factors that contribute to resistance. The study focuses on secondary EGFR mutations that emerge alongside the T790M mutation, which is known to contribute to resistance. The authors seek to understand how these mutations impact the efficacy of osimertinib, akin to mapping the intricate network of tunnels that connect different chambers in the cave.

Understanding the Complexities of Cancer Resistance

The study highlights the need to understand the mechanisms of resistance to targeted therapies. It's like deciphering the language of the desert, understanding the subtle signals that indicate shifts in the ecosystem. The researchers' findings could inform the development of new strategies to overcome resistance and improve treatment outcomes for patients with EGFR-mutated NSCLC.

Personalized Treatment Approaches for Cancer Patients

The study emphasizes the importance of individualized treatment plans in cancer care. It's like adapting your journey through the desert to the specific conditions you encounter. The research suggests that understanding the specific mutations that drive resistance can help clinicians tailor treatment strategies for each patient, maximizing the effectiveness of therapy and improving long-term outcomes.

Dr.Camel's Conclusion

This research delves into the hidden depths of cancer resistance, uncovering the intricate pathways that can undermine the effectiveness of targeted therapies. It's like exploring a labyrinthine desert, uncovering new secrets and understanding the complex interplay of forces that shape the landscape. By understanding these mechanisms, we can develop more effective treatment strategies, offering hope to patients battling this challenging disease.

Date :
  1. Date Completed 2019-09-30
  2. Date Revised 2022-06-03
Further Info :

Pubmed ID

30527179

DOI: Digital Object Identifier

10.1016/j.lungcan.2018.10.026

Related Literature

Article Analysis
・Effects of osimertinib・Effects of dacomitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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