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A crossover study of naproxen, diclofenac and tolmetin in seronegative juvenile chronic arthritis.

Author: AnsellB M, ClemensL E, HallM A, LeakA M, RichterM R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Naproxen, tolmetin, and diclofenac were all effective in treating juvenile chronic arthritis (JCA) in 28 children. The three drugs had comparable efficacy and tolerance, with naproxen and tolmetin having fewer side effects.
Paper Details　
Original Abstract of the Article :
Nonsteroidal anti-inflammatory drugs (NSAID) are useful in the management of juvenile chronic arthritis (JCA) and efficacy has usually been compared with aspirin. The disadvantages of aspirin include the frequency of dosage, monitoring of salicylate levels and concern about Reye's syndrome. We have ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/3052965

データ提供：米国国立医学図書館（NLM）

Treating Juvenile Chronic Arthritis: A Comparative Study of NSAIDs

The desert of juvenile chronic arthritis (JCA) can be a painful and debilitating experience for children. This study explores the efficacy of different nonsteroidal anti-inflammatory drugs (NSAIDs) in managing JCA. The authors compared naproxen, diclofenac, and tolmetin in a single-blind crossover study involving 28 children with seronegative JCA. The study aimed to determine the effectiveness and safety of these medications in managing the symptoms of JCA.

Comparable Efficacy and Tolerability

The study found that all three NSAIDs were effective in reducing the symptoms of JCA compared to baseline. While all three medications showed similar efficacy, naproxen and tolmetin had fewer side effects than diclofenac. This finding suggests that naproxen or diclofenac may be preferred as first-line treatments for children with JCA, due to their superior tolerability and widespread availability.

Navigating the Treatment Options

This study provides valuable insights for clinicians treating children with JCA. The findings highlight the importance of carefully considering the individual needs of each patient when choosing an NSAID. It is essential to balance the potential benefits of the medication with the risks of side effects, ensuring the best possible outcome for the child.

Dr. Camel's Conclusion

This study provides a valuable roadmap through the desert of JCA treatment options. The authors meticulously compared the efficacy and tolerability of three NSAIDs, offering clinicians valuable insights for choosing the most effective and safe treatment for their young patients. The study's findings are a testament to the ongoing efforts to improve the lives of children with this chronic condition.

Date :
  1. Date Completed 1988-12-12
  2. Date Revised 2017-01-12
Further Info :

Pubmed ID

3052965

DOI: Digital Object Identifier

3052965

Related Literature

Article Analysis
・Side Effects of tolmetin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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