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Renoprotective effects of tolvaptan in hypertensive heart failure rats depend on renal decongestion.

Author: AonumaKazutaka, ChibaHiroki, IshizuTomoko, NamekawaMikiko, SaiSeika, SeoYoshihiro

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the renoprotective effects of tolvaptan, a vasopressin type 2 receptor antagonist, in a hypertensive heart failure (HF) model. Tolvaptan significantly reduced central venous pressure and renal medullary pressure, improved renal medullary perfusion, and preserved creatinine clearance, demonstrating its potential renoprotective effects.
Paper Details　
Original Abstract of the Article :
The vasopressin type 2 receptor antagonist tolvaptan may have renoprotective effects in patients with heart failure (HF). This study aimed to reveal the renoprotective effect of tolvaptan from the viewpoint of hemodynamic combined with catheter and ultrasound examinations in a hypertensive HF model....See full text at original site
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引用元：
https://doi.org/10.1038/s41440-018-0169-3

データ提供：米国国立医学図書館（NLM）

Tolvaptan: A Potential Renoprotective Agent in Hypertensive Heart Failure

Heart failure is a serious condition that affects the heart's ability to pump blood effectively. This study investigates the renoprotective effects of tolvaptan, a vasopressin type 2 receptor antagonist, in rats with hypertensive heart failure.

Tolvaptan Shows Renoprotective Effects in Hypertensive Heart Failure Rats

This study examined the renoprotective effects of tolvaptan in a hypertensive heart failure rat model. The researchers found that tolvaptan reduced central venous pressure, renal medullary pressure, and improved renal medullary perfusion. These findings suggest that tolvaptan may have renoprotective effects by reducing renal congestion. This research is like discovering a new water source that can revitalize a parched desert landscape.

Potential for Tolvaptan in Treating Hypertensive Heart Failure

This study provides evidence that tolvaptan may have potential as a renoprotective agent in patients with hypertensive heart failure. The findings suggest that tolvaptan's renoprotective effects may be mediated by its ability to reduce renal congestion. This research opens up new possibilities for exploring tolvaptan as a potential treatment for hypertensive heart failure.

Dr.Camel's Conclusion

This study suggests that tolvaptan may be a promising renoprotective agent for patients with hypertensive heart failure. The findings highlight the potential of this medication to improve renal function by reducing congestion. This research offers hope for developing new and effective treatments for this challenging condition.

Date :
  1. Date Completed 2020-08-25
  2. Date Revised 2020-08-25
Further Info :

Pubmed ID

30559403

DOI: Digital Object Identifier

10.1038/s41440-018-0169-3

Related Literature

Article Analysis
・Effects of tolvaptan (low blood sodium)
SNS
PICO Info
in preparation
Languages

English

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