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Potential Dangers of Serum Urate-Lowering Therapy.

Author: BartschLorenz-Alexander, Castillo-RodriguezEsmeralda, Fernandez-PradoRaul, KanbayMehmet, OrtizAlberto, Perez-GomezMaria Vanessa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Lowering uric acid levels with medication has been linked to higher mortality in gout patients in several clinical trials, despite observational studies showing a link between high uric acid and adverse outcomes. These trials observed higher mortality with greater uric acid reduction, suggesting a potential safety concern. Uric acid acts as an antioxidant, and further research is needed to determine the optimal uric acid levels and the safety of lowering it below certain thresholds.
Paper Details　
Original Abstract of the Article :
In observational studies, high serum urate levels are associated with adverse outcomes, including mortality. However, the hypothesis that urate-lowering may improve nongout outcomes has not been confirmed by placebo-controlled clinical trials. On the contrary, 7 recent placebo-controlled trials of u...See full text at original site
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引用元：
https://doi.org/10.1016/j.amjmed.2018.12.010

データ提供：米国国立医学図書館（NLM）

Exploring the Potential Dangers of Serum Urate-Lowering Therapy

This study delves into the complex and often controversial topic of serum urate-lowering therapy. It examines the potential risks associated with lowering serum urate levels, especially in the context of gout. This research challenges the prevailing notion that lowering urate is always beneficial and raises concerns about potential unintended consequences. It's like venturing into a treacherous desert, where seemingly simple solutions can lead to unforeseen complications.

Unraveling the Mystery of Urate-Lowering Therapy

The study found that while high serum urate levels have been linked to negative health outcomes, the assumption that lowering urate is always beneficial has not been fully supported by clinical trials. In fact, some studies have observed higher mortality rates in gout patients who underwent more intense urate-lowering therapy. This suggests a more nuanced relationship between urate levels and health outcomes. It's like discovering a hidden oasis in the desert, where the true nature of urate-lowering therapy is more complex than previously thought.

Navigating the Desert of Gout Management

This research highlights the importance of carefully considering the risks and benefits of urate-lowering therapy. It emphasizes the need for a personalized approach to gout management, taking into account individual patient factors and the potential for adverse outcomes. It's like navigating a challenging desert landscape, where the path to optimal health requires a careful balance of resources and strategies.

Dr.Camel's Conclusion

This study raises important questions about the potential risks of serum urate-lowering therapy, prompting a deeper understanding of the complex relationship between urate levels and health outcomes. It's a reminder that even in the vast desert of medical knowledge, there are still mysteries to unravel and challenges to overcome.
Date :
  1. Date Completed 2019-12-27
  2. Date Revised 2019-12-27
Further Info :

Pubmed ID

30611833

DOI: Digital Object Identifier

10.1016/j.amjmed.2018.12.010

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Languages

English

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