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The effects of zonisamide on L-DOPA-induced dyskinesia in Parkinson's disease model mice.

Author: NambuAtsushi, SanoHiromi

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of zonisamide on L-DOPA-induced dyskinesia in a Parkinson's disease (PD) mouse model. Zonisamide worsened dyskinesia and altered neuronal activity in the substantia nigra pars reticulata, suggesting a potential role in modulating basal ganglia function.
Paper Details　
Original Abstract of the Article :
Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the midbrain and shows motor dysfunctions. Zonisamide (ZNS, 1,2-benzisoxazole-3-methanesulfonamide), which was originally developed as an antiepileptic drug, was also found to have beneficial effec...See full text at original site
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引用元：
https://doi.org/10.1016/j.neuint.2019.01.011

データ提供：米国国立医学図書館（NLM）

Zonisamide: A Double-Edged Sword in the Treatment of Parkinson's Disease

This study investigates the effects of zonisamide (ZNS), a drug typically used for epilepsy, on L-DOPA-induced dyskinesia (LID), a debilitating movement disorder that can occur in patients with Parkinson’s disease (PD) treated with L-DOPA. While ZNS has been shown to have beneficial effects on motor symptoms in PD, the study reveals that chronic administration of ZNS alongside L-DOPA can paradoxically worsen LID, leading to an increase in the duration and severity of involuntary movements. The researchers explored the underlying neural mechanisms responsible for this effect, analyzing neuronal activity in the substantia nigra pars reticulata (SNr), a key brain region involved in movement control. Their findings suggest that ZNS may alter the balance of activity between the direct and indirect pathways in the basal ganglia, potentially contributing to the worsening of LID.

The Complexities of Parkinson’s Disease: A Delicate Balance

This study highlights the intricate interplay of different brain regions and pathways in Parkinson’s disease. It reveals that seemingly beneficial drugs can have unintended consequences, emphasizing the importance of careful monitoring and understanding the potential side effects of medications.

Navigating the Labyrinth of Parkinson’s Treatment: A Multi-faceted Approach

Managing Parkinson’s disease requires a comprehensive approach that addresses both motor and non-motor symptoms. This study underscores the need for close monitoring and personalized treatment strategies to optimize outcomes and mitigate potential side effects.

Dr. Camel's Conclusion

This research underscores the complexities of treating Parkinson’s disease, a condition that can be as unpredictable as a sandstorm in the desert. It highlights the importance of a cautious and individualized approach to medication, ensuring that benefits outweigh potential risks.
Date :
  1. Date Completed 2019-12-24
  2. Date Revised 2019-12-24
Further Info :

Pubmed ID

30639196

DOI: Digital Object Identifier

10.1016/j.neuint.2019.01.011

Related Literature

Article Analysis
・Effects of zonisamide
SNS
PICO Info
in preparation
Languages

English

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