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Acute kidney injury: an unusual complication of posaconazole use.

Author: BongominFelix, DenningDavid W, KosmidisChris, OtuAkaninyene

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Posaconazole, a triazole antifungal drug, is generally well-tolerated but can cause side effects including kidney injury. This report describes two cases of acute kidney injury (AKI) in a patient treated with posaconazole for Aspergillus lung infection, highlighting the importance of monitoring renal function during posaconazole therapy.
Paper Details　
Original Abstract of the Article :
Triazole antifungals are useful in the treatment of Aspergillus disease and these drugs have side effects which clinicians should be aware of. Posaconazole is an orally administered second-generation triazole antifungal agent which inhibits lanosterol 14-alpha-demethylase, an enzyme that converts la...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1080/1120009X.2018.1522472

データ提供：米国国立医学図書館（NLM）

Posaconazole and AKI: Navigating the Dunes of Antifungal Therapy

The desert of antifungal therapy can be a challenging landscape to navigate, particularly for patients with weakened immune systems. This study explores the potential for posaconazole, an antifungal drug, to cause acute kidney injury (AKI). Researchers, like explorers venturing into uncharted territory, describe two episodes of AKI in a patient receiving posaconazole for Aspergillus lung disease. This finding highlights the importance of vigilant monitoring of renal function in patients receiving this antifungal medication, as early detection and intervention can help prevent serious complications.

Navigating the Risks of Antifungal Therapy

This study serves as a reminder that even seemingly well-tolerated medications can carry unexpected risks. While posaconazole is generally considered safe and effective, it's crucial to be aware of the potential for AKI and to monitor patients closely for any signs of kidney dysfunction. This research underscores the need for a cautious and vigilant approach to antifungal therapy, ensuring that patients receive appropriate care and minimize the risk of complications.

Staying Safe in the Desert of Antifungal Therapy

This study highlights the importance of open communication between patients and healthcare professionals regarding potential side effects and risks associated with medications. While posaconazole can be an effective treatment for fungal infections, it's crucial to be aware of the potential for AKI and to seek medical attention immediately if any concerning symptoms arise. Remember, staying informed and vigilant can help you safely navigate the dunes of antifungal therapy and maintain your overall health.

Dr.Camel's Conclusion

This study reminds us that even in the desert of antifungal therapy, where seemingly safe havens exist, unexpected challenges can arise. Vigilant monitoring of renal function in patients receiving posaconazole is crucial, allowing us to swiftly address any potential complications and ensure optimal patient outcomes.

Date :
  1. Date Completed 2019-05-02
  2. Date Revised 2019-05-02
Further Info :

Pubmed ID

30663547

DOI: Digital Object Identifier

10.1080/1120009X.2018.1522472

Related Literature

Article Analysis
・Side Effects of posaconazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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