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Tapentadol: an analgesic that differs from classic opioids due to its noradrenergic mechanism of action.

Author: CandelettiSanzio, CaputiFrancesca F, NicoraMariaflavia, RomualdiPatrizia, SimeoneRoberto

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Chronic pain is a complex challenge, and opioids, while effective, carry risks of side effects and dependence. Tapentadol, a new type of analgesic, combines µ-opioid receptor agonism with noradrenaline reuptake inhibition (NRI), offering a unique profile for treating chronic pain. This review discusses tapentadol's efficacy and safety profile in various pain models and clinical settings, highlighting its potential as a novel treatment option.
Paper Details　
Original Abstract of the Article :
Chronic pain treatment represents one of the most complex clinical challenges and even though opioids exhibit particular efficacy on nociceptive pain, their use must be controlled to avoid the risk of adverse reactions. A useful approach, aimed at maintaining analgesia and mitigating side effects, i...See full text at original site
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引用元：
https://doi.org/10.23736/S0026-4806.18.05909-8

データ提供：米国国立医学図書館（NLM）

Tapentadol: A Unique Analgesic with Dual Mechanisms of Action

This review examines the analgesic properties of tapentadol, a novel medication that offers a distinct approach to pain management. The authors recognize the challenges associated with chronic pain management, particularly the risks associated with opioid use. The review delves into the unique mechanism of action of tapentadol, which combines µ-opioid receptor agonism and noradrenaline reuptake inhibition. The authors explore tapentadol's efficacy and tolerability profile, seeking to provide a comprehensive overview of its potential as a safe and effective analgesic.

Tapentadol's Unique Analgesic Profile

The review highlights tapentadol's unique analgesic profile, emphasizing its dual mechanisms of action. The combination of µ-opioid receptor agonism and noradrenaline reuptake inhibition allows tapentadol to provide effective pain relief while potentially minimizing the risks associated with traditional opioids. The review also underscores tapentadol's favorable tolerability profile, particularly its good gastrointestinal tolerability and minimal impact on hormone levels and cognitive performance.

A Promising Option for Chronic Pain Management

This review presents tapentadol as a promising option for managing chronic pain. The authors emphasize its unique analgesic profile, combining effective pain relief with a favorable tolerability profile. The review encourages further research to explore tapentadol's potential in various pain conditions and to further define its long-term safety and efficacy.

Dr.Camel's Conclusion

This review introduces us to tapentadol, a novel analgesic that offers a unique approach to pain management. The authors' comprehensive analysis highlights tapentadol's potential benefits, including its dual mechanisms of action and favorable tolerability profile. The review encourages further exploration of tapentadol's role in managing chronic pain, potentially offering a safer and more effective alternative to traditional opioid-based therapies.

Date :
  1. Date Completed 2019-02-07
  2. Date Revised 2019-02-15
Further Info :

Pubmed ID

30667206

DOI: Digital Object Identifier

10.23736/S0026-4806.18.05909-8

Related Literature

Article Analysis
・Side Effects of tapentadol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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