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Mineralocorticoid Antagonism and Diabetic Kidney Disease.

Author: CherneyDavid Z, GodoyLucas C, LytvynYuliya, ScholtesRosalie A, van RaalteDaniël H

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Type 2 diabetes is associated with a higher risk of kidney disease, cardiovascular disease, and heart failure. While newer medications like SGLT-2 inhibitors and GLP-1 receptor agonists help reduce these risks, there's still a need for better treatments. This review explores the potential of novel mineralocorticoid receptor antagonists (MRAs) to further reduce these complications in people with type 2 diabetes.
Paper Details　
Original Abstract of the Article :
Type 2 diabetes (T2D) is associated with an increased risk of diabetic kidney disease (DKD), cardiovascular disease, and heart failure, in part through activation of the renin-angiotensin-aldosterone system (RAAS). Although recent cardiovascular outcome trials have identified newer therapeutic agent...See full text at original site
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引用元：
https://doi.org/10.1007/s11892-019-1123-8

データ提供：米国国立医学図書館（NLM）

Mineralocorticoid Antagonism: Fighting Diabetes-Related Kidney Disease

Type 2 diabetes is a widespread health concern, and this study focuses on its impact on the kidneys, specifically diabetic kidney disease (DKD). The researchers explore the role of the renin-angiotensin-aldosterone system (RAAS), a key regulatory pathway for blood pressure and fluid balance, in the development of DKD. They also discuss the potential of mineralocorticoid receptor antagonists (MRAs), drugs that block the effects of aldosterone, a hormone produced by the RAAS, as a new treatment approach for DKD.

A New Frontier in Diabetes Treatment

The study highlights the promise of MRAs in reducing the risk of DKD and cardiovascular disease in patients with type 2 diabetes. The researchers emphasize the need for further research to determine the optimal role of MRAs in treating DKD and to identify the most effective combination therapies. This study offers a new perspective on managing diabetes-related kidney disease, potentially paving the way for improved treatment strategies.

Managing Diabetes: A Desert of Challenges

This research highlights the complexity of managing type 2 diabetes and its associated complications. Just as a camel caravan encounters various challenges in the desert, patients with diabetes need to navigate a multifaceted approach to managing their condition. This includes maintaining a healthy lifestyle, adhering to medication regimens, and seeking regular medical follow-up to minimize the risk of complications like DKD.

Dr.Camel's Conclusion

This study explores the potential of mineralocorticoid receptor antagonists (MRAs) as a novel therapeutic approach for diabetic kidney disease (DKD). The researchers, like explorers seeking new routes in the desert, are uncovering promising pathways for managing this complex complication of diabetes. The study emphasizes the need for continued research to optimize the use of MRAs and to identify effective combination therapies for DKD.
Date :
  1. Date Completed 2019-12-10
  2. Date Revised 2021-07-21
Further Info :

Pubmed ID

30673886

DOI: Digital Object Identifier

10.1007/s11892-019-1123-8

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Languages

English

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