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Synthesis and characterization of a novel biocompatible pseudo-hexagonal NaCa-layered double metal hydroxides for smart pH-responsive drug release of dacarbazine and enhanced anticancer activity in malignant melanoma.
Author: AlipourMohsen, AsiabiHamid, HosseinkhaniSaman, ShamsayeiMaryam, YaminiYadollah
Original Abstract of the Article :
Layered metal hydroxides have exhibited remarkable benefits in drug delivery, days or even weeks of continuous drug release with improved bioavailability and minimized adverse effects. Here, we report synthesis of a new M<sup>+</sup> (Na<sup>+</sup>) and M<sup>2+</sup> (Ca<sup>2+</sup>) layered doub...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1016/j.msec.2018.12.017
データ提供:米国国立医学図書館(NLM)
Layered Double Metal Hydroxides: A Novel Oasis in the Desert of Cancer Treatment
This study explores the potential of layered double metal hydroxides (LDHs), a class of materials with unique properties, as a drug delivery system for treating cancer. It's like venturing into a vast desert, seeking new pathways to combat the challenges of cancer therapy. This study focused on the development of a novel NaCa-LDH, a biocompatible and pH-sensitive material, for the controlled release of dacarbazine, a chemotherapy drug used to treat various cancers. This study is like discovering a hidden oasis of innovation, offering a potential solution to overcome the limitations of conventional chemotherapy.
Delivering Chemotherapy With Precision: A Controlled Release System
The study demonstrated that NaCa-LDH could effectively intercalate dacarbazine, achieving a high drug loading capacity. The release of dacarbazine from NaCa-LDH was found to be pH-sensitive, releasing the drug more effectively at lower pH levels, mimicking the acidic environment of tumors. It's like creating a smart delivery system that targets the cancer cells while minimizing damage to healthy tissues. This unique approach to drug delivery has the potential to enhance the efficacy of chemotherapy while reducing its side effects.
A Beacon of Hope in the Desert of Cancer Treatment
This study highlights the potential of NaCa-LDH as a promising platform for developing smart drug delivery systems for a wide range of applications. It's like discovering a new pathway through the desert of cancer treatment, offering a more targeted and effective approach to battling this devastating disease. This innovative approach offers a glimmer of hope for those seeking effective and less toxic treatments for cancer.
Dr.Camel's Conclusion
This study offers a promising new approach to delivering chemotherapy drugs, highlighting the potential of NaCa-LDH as a novel and effective drug delivery system. It's like finding a hidden oasis of innovation in the desert of cancer treatment, offering a new path towards more targeted and effective therapies.
Date :
- Date Completed 2019-06-17
- Date Revised 2019-06-17
Further Info :
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