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The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice.

Author: BronsonRoderick T, CrottJimmy W, HuangYueyi, KohGar Yee, MasonJoel B, WuXian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

High-fat diets (HFDs) and adiposity increase colorectal cancer risk through inflammation. Curcumin (CUR) and salsalate (SAL) are known to suppress inflammatory signaling, but through different pathways. This study investigates the potential synergistic effects of CUR and SAL in suppressing inflammation and potentially reducing colorectal cancer risk in the context of HFDs and adiposity.
Paper Details　
Original Abstract of the Article :
High-fat diets (HFDs) and adiposity increase colorectal cancer risk, in part by elevating pro-inflammatory cytokines that activate pro-cancerous signaling pathways. Curcumin (CUR), a dietary polyphenol and salsalate (SAL), an non-steroidal anti-inflammatory drug (NSAID) lacking the gastrotoxicity of...See full text at original site
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引用元：
https://doi.org/10.1002/mnfr.201801097

データ提供：米国国立医学図書館（NLM）

Curcumin and Salsalate: A Powerful Combination in Combating Colorectal Cancer

This research delves into the intriguing realm of cancer prevention and treatment. This study investigates the potential of curcumin and salsalate in suppressing colorectal cancer development, particularly in the context of obesity. The researchers focused on the role of these agents in inhibiting pro-cancerous molecular pathways. They compared the effects of curcumin and salsalate individually and in combination, seeking to understand their synergistic effects on tumorigenesis. This research provides valuable insights into the potential of these natural and pharmaceutical compounds in combating colorectal cancer.

Curcumin and Salsalate: A Promising Combination for Colorectal Cancer Prevention

The study demonstrates the effectiveness of the combination of curcumin and salsalate in suppressing colorectal tumorigenesis. [研究結果] This research highlights the potential of these agents, either individually or in combination, in preventing or treating colorectal cancer, particularly in individuals with obesity.

Health Implications and Lifestyle Considerations

This research emphasizes the importance of a healthy lifestyle and dietary choices in preventing colorectal cancer. [健康的なベネフィットもしくはリスク] It encourages individuals to incorporate foods rich in curcumin, such as turmeric, into their diets and to consult with healthcare professionals for personalized advice on managing colorectal cancer risk.

Dr.Camel's Conclusion

This research offers a promising avenue for exploring natural and pharmaceutical approaches to combat colorectal cancer. It highlights the potential of curcumin and salsalate, either individually or in combination, in preventing or treating colorectal cancer. The study encourages further research to fully understand the mechanisms and applications of these agents in cancer management.

Date :
  1. Date Completed 2019-11-08
  2. Date Revised 2019-11-08
Further Info :

Pubmed ID

30680927

DOI: Digital Object Identifier

10.1002/mnfr.201801097

Related Literature

Article Analysis
・Effects of salsalate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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