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LC-MS/MS-Based Quantification of 9 Antiepileptic Drugs From a Dried Sample Spot Device.

Author: BarcoSebastiano, CangemiGiuliana, DʼAvolioAntonio, DʼUrsoAnnachiara, StrianoPasquale, de GraziaUgo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is typically done using plasma or serum, but dried plasma spots (DPSs) may offer a more convenient option for sample shipment to laboratories. This study examined the use of a commercially available UHPLC-MS/MS method to determine the levels of 9 commonly prescribed AEDs in DPS collected on dried sample spot devices (DSSDs).
Paper Details　
Original Abstract of the Article :
Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is commonly performed on plasma or serum. The use of dried plasma spots (DPSs) could represent a useful tool to facilitate sample shipment to reference laboratories. In this article, the authors describe the application of a commerciall...See full text at original site
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引用元：
https://doi.org/10.1097/FTD.0000000000000600

データ提供：米国国立医学図書館（NLM）

Revolutionizing Antiepileptic Drug Monitoring: Dried Sample Spots as a New Frontier

Therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is a crucial aspect of managing epilepsy. Traditionally, TDM relies on blood samples, which can be cumbersome and time-consuming. This study, led by Dr. [Author's last name], explored the potential of using dried plasma spots (DPSs) collected on dried sample spot devices (DSSDs) for AED monitoring. The researchers aimed to develop a reliable and convenient method for TDM, simplifying the process for both patients and healthcare professionals.

A New Oasis in the Desert of Drug Monitoring

The study successfully demonstrated the application of a commercially available UHPLC-MS/MS method for the determination of 9 commonly prescribed AEDs in DPSs collected on DSSDs. This innovative approach offers a promising alternative to traditional blood sampling, potentially making TDM more accessible and convenient. It's like discovering a hidden oasis in the desert of drug monitoring – a new and efficient way to monitor treatment.

Simplifying the Journey: A New Era of Drug Monitoring

This research has the potential to revolutionize AED monitoring, making it easier for patients to participate in TDM and for healthcare providers to effectively manage their treatment. It's a reminder that innovation and technological advancements can significantly improve healthcare delivery and patient experiences. It's a new path through the desert, leading to a more efficient and accessible approach to drug monitoring.

Dr.Camel's Conclusion

This research opens up exciting possibilities for simplifying AED monitoring. By utilizing DPSs collected on DSSDs, we can make TDM more convenient and accessible for patients, ultimately leading to improved treatment outcomes. It's a testament to the ongoing advancements in healthcare and the potential for innovation to transform patient care. It's like discovering a new oasis in the desert of drug monitoring – a beacon of hope for a more efficient and effective future.

Date :
  1. Date Completed 2020-01-16
  2. Date Revised 2020-01-16
Further Info :

Pubmed ID

30688867

DOI: Digital Object Identifier

10.1097/FTD.0000000000000600

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English

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