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Localized Delivery of Pilocarpine to Hypofunctional Salivary Glands through Electrospun Nanofiber Mats: An Ex Vivo and In Vivo Study.

Author: AdineChristabella, DavoodiPooya, FerreiraJoao N, MuthumariappanSujatha, NgKiaw Kiaw, NgWei Cheng, WangChi-Hwa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A new localized formulation of pilocarpine, a drug used to treat dry mouth, has been developed using PLGA/PEG nanofiber mats. This formulation demonstrated high encapsulation efficiency and sustained release of pilocarpine, which significantly increased salivary secretion in vivo. This study highlights the potential of this formulation for future clinical translation in patients with xerostomia.
Paper Details　
Original Abstract of the Article :
Dry mouth or xerostomia is a frequent medical condition among the polymedicated elderly population. Systemic pilocarpine is included in the first line of pharmacological therapies for xerostomia. However, the efficacy of existing pilocarpine formulations is limited due to its adverse side effects an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387464/

データ提供：米国国立医学図書館（NLM）

A Nanofiber Solution for Dry Mouth: Localized Delivery of Pilocarpine

This study explores the potential of electrospun nanofiber mats as a novel delivery system for pilocarpine, a medication used to treat dry mouth (xerostomia). Xerostomia is a common condition that can significantly impact quality of life, making it difficult to eat, speak, and swallow. The study investigated the efficacy of pilocarpine-loaded nanofiber mats in stimulating saliva secretion both ex vivo and in vivo.

Electrospun Nanofiber Mats: A Targeted Approach to Dry Mouth Treatment

The study found that pilocarpine-loaded nanofiber mats effectively stimulated saliva secretion in both ex vivo and in vivo models. The nanofiber mats were biocompatible and delivered pilocarpine directly to the salivary glands, leading to a significant increase in saliva production. The researchers believe that this approach could provide a more effective and convenient treatment for xerostomia compared to traditional systemic pilocarpine formulations.

A Breath of Fresh Air for Dry Mouth Sufferers: A New Treatment Horizon

This research offers a promising new approach to treating dry mouth by using electrospun nanofiber mats to deliver pilocarpine directly to the salivary glands. This approach could potentially improve the efficacy and convenience of treatment, leading to a better quality of life for patients. Imagine a thirsty camel in the desert; this new approach could provide a refreshing oasis of relief, allowing them to thrive in even the harshest conditions.

Dr. Camel's Conclusion

This study presents a novel approach to treating dry mouth by using electrospun nanofiber mats to deliver pilocarpine directly to the salivary glands. This innovative technology could potentially improve the efficacy and convenience of treatment, offering a brighter future for patients struggling with this common condition. Just like a camel adapting to the arid desert landscape, researchers are constantly seeking new ways to address the challenges of human health, finding innovative solutions that can improve the lives of millions.
Date :
  1. Date Completed 2019-06-04
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

30696017

DOI: Digital Object Identifier

PMC6387464

Related Literature

Article Analysis
・Side Effects of pilocarpine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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