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The Development of a Macromolecular Analgesic for Arthritic Pain.

Author: PangHuiling, RenRongguo, WangDong, WangHanjun, WangXiaobei, WeberLaura, WeiXin, YangJunxiao, YuanHongjiang, ZhaoGang

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study developed a novel inflammation-targeting polymeric prodrug of hydromorphone (HMP), a commonly used opioid, to reduce its addictive potential and improve its effectiveness for musculoskeletal pain. The prodrug, P-HMP, was shown to be internalized by inflammatory cells in arthritic joints, effectively alleviating pain while minimizing central nervous system effects.
Paper Details　
Original Abstract of the Article :
The addictive potential of clinically used opioids as a result of their direct action on the dopaminergic reward system in the brain has limited their application. In an attempt to reduce negative side effects as well as to improve the overall effectiveness of these analgesics, we have designed, syn...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/30702897

データ提供：米国国立医学図書館（NLM）

Macromolecular Analgesics: A New Frontier in Pain Management

Opioids, while effective for pain relief, carry the risk of addiction and other side effects. This study explored a novel approach to pain management using a macromolecular prodrug of hydromorphone, a commonly used opioid. The researchers designed and synthesized a HPMA-based macromolecular prodrug, aiming to deliver hydromorphone directly to the arthritic joint, potentially reducing systemic exposure and minimizing side effects.

The study demonstrated that the macromolecular prodrug effectively targeted the arthritic joint in a rodent model, providing pain relief comparable to dose-equivalent hydromorphone. The prodrug exhibited a reduced spinal cord analgesia compared to free hydromorphone, suggesting a more localized action at the site of inflammation. These findings highlight the potential of macromolecular prodrugs as a safer and more effective approach to pain management in arthritis.

Macromolecular Prodrugs: A New Oasis in the Desert of Pain

Chronic pain can be a debilitating condition, like a vast and unforgiving desert. This study explores the potential of macromolecular prodrugs as a new oasis of relief, offering a potentially safer and more effective approach to pain management. By targeting the site of inflammation, these prodrugs could reduce systemic exposure to opioids, minimizing the risk of addiction and other side effects.

Navigating the Desert of Pain: A Smoother Journey

Chronic pain is a challenging condition that can significantly impact quality of life. This study offers a glimmer of hope, exploring a novel approach to pain management that could provide a smoother and potentially safer journey for patients. Macromolecular prodrugs, like a skilled caravan navigating a treacherous desert, could deliver pain relief directly to the source, minimizing systemic exposure and potential side effects.

Dr.Camel's Conclusion

Chronic pain is a harsh and relentless desert, but this study points to a new oasis of hope: macromolecular prodrugs. These innovative medications could provide targeted pain relief, minimizing systemic exposure and potential side effects, offering a smoother and more comfortable journey for patients seeking relief from their pain.

Date :
  1. Date Completed 2019-12-11
  2. Date Revised 2023-10-06
Further Info :

Pubmed ID

30702897

DOI: Digital Object Identifier

NIHMS1010713

Related Literature

Article Analysis
・Side Effects of hydromorphone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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